141077-52-3

Upstream product

• 2033-89-8 3,4-dimethoxyphenol 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 1005350-64-0 (R)-2-methyl-2-(3,4-dimethoxyphenyl)-1-tetralone 
• 1456071-23-0 3-(3,4-dimethoxybenzoyl)-2H-chromen-2-one 
• 124244-44-6 (S)-2-(naphthalen-2-yl)-2,3-dihydrofuran 
• 124244-45-7 (2S,5S)-2-(3,4-Dimethoxy-phenyl)-5-naphthalen-2-yl-2,5-dihydro-furan 
• 141195-16-6 (2R,5R)-2-(3,4-Dimethoxy-phenyl)-5-naphthalen-2-yl-2,5-dihydro-furan 
• 131516-09-1 (R)-2,3-dihydro-2-(naphthalen-2-yl)furan 
• 1384863-15-3 N-(3,4-dimethoxyphenyl)-3-nitrobenzimidamide 
• 1363337-22-7 N-(3,4-dimethoxyphenyl)thiazol-2-amine 
• 1316240-23-9 (3R)-(3,4-dimethoxyphenyl)-(4S)-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene 

Relevant academic research and scientific papers

Mechanistic study of a Pd/C-catalyzed reduction of aryl sulfonates using the Mg-MeOH-NH4OAc system

A method for the deoxygenation of phenolic hydroxy groups via aryl triflates or mesylates has been established by using a combination of Pd/ C-Mg-MeOH. The addition of NH4OAc to the system markedly accelerated the reaction rate and expanded the scope of the reaction. Mechanistic studies suggested that a single-electron transfer process from the Pd0 center to the benzene ring is involved in the reduction of aryl sulfonates and that NH4OAc works as a solubilization re agent of the Mg salt and as an accelerator of the electron transfer, thus enhancing the reaction process. Our method was also applicable to the regioselective deuteration of benzene derivatives with CH3OD as the solvent and deuterium source: the original hydroxy group could be efficiently replaced with a deuterium atom.

Achieving vinylic selectivity in Mizoroki-heck reaction of cyclic olefins

In Heck reactions of cyclic olefins, the products usually have aryl groups that end up at the allylic and/or homoallylic position. We herein report new selectivity that adds aryl groups to the vinylic position. Cyclic olefins of various ring size worked well. The desired isomers were produced by palladium-hydride-catalyzed isomerization of the initial products. Thus, a specific catalyst must be used so that it can perform two jobs under one set of reaction conditions. Copyright

Synthesis and biological activity of optically active phenylbutenoid dimers

The total synthesis of optically active phenylbutenoid dimers 1, 3, and ent-3 is described. The key step to access optically active cyclohexene rings was achieved by Diels-Alder reaction of chiral acryloyloxazolinone 9 and phenylbetadiene 10.

Palladium on carbon-diethylamine-mediated hydrodeoxygenation of phenol derivatives under mild conditions

We have found that phenolic hydroxyl groups were readily deoxygenated via aryl sulfonate under the Pd/C-catalyzed hydrogenation conditions in the presence of diethylamine and the method could also be applicable to the hydrodeoxygenation of morphine to afford 3-deoxy-7,8-dihydromorphine. Diethylamine is not only a scavenger of the corresponding methanesulfonic acid derivative, which is produced during the reaction progress, but also a strong promoter of the Pd/C-catalyzed reduction of aryl sulfonates. This catalyst system could provide a general method for the deoxygenation of various phenol derivatives because of its mild reaction conditions, ease of handling, and no need of particular apparatus.