141082-03-3Relevant academic research and scientific papers
Chiral oxazoline route to enantiomerically pure biphenyls: Magnesio and copper mediated asymmetric hetero- and homo-coupling reactions
Meyers,Nelson, Todd D.,Moorlag, Henk,Rawson, David J.,Meier, Anton
, p. 4459 - 4473 (2004)
A series of chiral biphenyls were prepared via asymmetric reactions involving chiral oxazolines. One series of chiral biphenyls was reached by the magnesium mediated coupling of aryl bromides (via their Grignard reagents) with o-methoxyaryl oxazolines. In
A highly stereoselective synthesis of axially chiral biaryls. Application to the synthesis of a potential chiral catalyst
Meyers,Meier,Rawson
, p. 853 - 856 (2007/10/02)
Excellent diastereoselectivities (>98.2) have been obtained in the biaryl coupling of 2',6',-disubstituted aryl Grignard reagents 1 with aryl oxazolines 6, conveniently synthesised from the optically pure amino alcohols L-valinol and (S)-t-leucinol.
