1410825-75-0Relevant academic research and scientific papers
Isoprene as lithiation mediator: Synthesis of 2-substituted 1-alkylimidazole derivatives
Martinez, Regina,Torregrosa, Rosario,Pastor, Isidro M.,Yus, Miguel
experimental part, p. 2630 - 2638 (2012/09/07)
The lithiation of different imidazoles bearing a primary (i.e., butyl, pentyl, dodecyl) or secondary (i.e., cyclohexyl, 1-methylheptyl) alkyl substituent on the nitrogen has been successfully achieved by means of an isoprene-mediated protocol. The subsequent reaction of the 2-lithioimidazole intermediates with different electrophiles leads to the formation of interesting 1,2-disubstituted imidazoles. Georg Thieme Verlag Stuttgart · New York.
