1410876-59-3Relevant academic research and scientific papers
Facile synthesis of fully substituted dihydro-β-carbolines via Bronsted acid promoted cascade reactions of α-indolyl propargylic alcohols with nitrones
Wang, Lu,Xie, Xin,Liu, Yuanhong
, p. 5848 - 5851 (2013/02/23)
A straightforward synthesis of fully substituted β-carbolines via Bronsted acid promoted cyclizations of α-indolyl propargylic alcohols with nitrones is described. The use of nitrones bearing alkenyl or electron-rich aryl groups as the R4 substituent dramatically switches the reaction pathway to afford tetrasubstituted alkenes and amines, which is assumed to proceed through a rearrangement reaction involving N-O bond cleavage and 1,2-migration of the R4 group to an adjacent nitrogen atom.
