710975-90-9

Upstream product

• 69622-35-1 1-(1H-indol-3-yl)-2,2-dimethylpropan-1-one 
• 100-39-0 benzyl bromide 
• 3377-71-7 N-benzylindole 
• 3282-30-2 pivaloyl chloride 
• 120-72-9 indole 
• 603-76-9 1-methylindole 

Downstream Products

• 1410876-59-3 C₄₁H₃₆N₂O 
• 1410877-25-6 3-(1-benzyl-1H-indol-3-yl)-4,4-dimethyl-1-phenylpent-1-yn-3-ol 
• 481630-63-1 1-benzyl-4-(4-(trifluoromethoxy)phenyl)-1H-indole 
• 481630-46-0 1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indole 
• 481630-49-3 1-Benzyl₄-[4-(trifluoromethyl)phenyl]-1H-indole 
• 393105-53-8 2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)oxoacetic acid 

Relevant academic research and scientific papers

Weak Coordination Enabled Switchable C4-Alkenylation and Alkylation of Indoles with Allyl Alcohols

A weak carbonyl coordination facilitated tunable reactivity between alkenylation and alkylation of indoles at the C4 C-H site is presented using readily accessible allylic alcohols in the presence of Rh catalysis by switching the additives or directing group. Exclusive site selectivity, functional group tolerance, and late-stage modifications are the important practical features.

Palladium-Catalyzed 2-fold C-H Activation/C-C Coupling for C4-Arylation of Indoles Using Weak Chelation

Palladium-catalyzed weak chelation-assisted regioselective C4-arylation of indoles has been accomplished using a readily available arene at moderate temperature. The C4-arylation, weak chelating benzoyl (Bz) directing group, cross-dehydrogenative coupling (CDC), broad substrate scope, and late-stage diversifications are the important practical features.

Cascade Reaction to Selectively Synthesize Multifunctional Indole Derivatives by IrIII-Catalyzed C?H Activation

An effective and condition-controlled way to synthesize with high selectivity a variety of functionalized indoles with potent biological properties has been developed. Notably, 2,4-dialkynyl indole products were obtained by direct double C?H bond alkynylation, whereas alkynyl at the C4 position could convert to carbonyl to generate 2-alkynyl-3,4-diacetyl indoles fast and effectively. Additionally, a one-pot relay catalytic reaction led to 2,5-di-alkynyl-3,4-diacetyl indoles when using a carbonyl group as the directing group and by controlling the type and quantity of additives. A possible mechanism was proposed based on many studies including deuterium-exchange experiments, the necessary conditions of product conversion, and the effect of water on the reaction.

Regiocontrolled Direct C?H Arylation of Indoles at the C4 and C5 Positions

An effective and practical strategy has been established for the direct and site-selective arylation of indoles at the C4 and C5 positions with the aid of a readily accessible, cheap, and removable pivaloyl directing group at the C3 position. This transfo

Nucleophilic addition of grignard reagents to 3-acylindoles: Stereoselective synthesis of highly substituted indoline scaffolds

3-Acylindoles undergo nucleophilic-type reactions with Grignard reagents to efficiently afford either cis- or trans-substituted indolines, depending on the different quenching procedures. The enolate intermediate could be trapped by aryl acyl chlorides to provide indolines bearing a quaternary carbon center with high stereoselectivity. In contrast, the use of benzyl bromide as an electrophile results in the fragmentation of the indole ring. The indoline products could be easily transformed into indoles through oxidation with DDQ in a one-pot manner.