1411642-24-4Relevant academic research and scientific papers
A new synthesis of N-substituted -trifluoroacetylanilines
Shidlovskii, Alexander F.,Golubev, Alexander S.,Gusev, Dmitrii V.,Suponitsky, Kyrill Yu.,Peregudov, Alexander S.,Chkanikov, Nikolai D.
, p. 272 - 280,9 (2020/07/31)
A method for the synthesis of N-substituted -trifluoroacetylanilines by the reaction of N-substituted isatoic anhydrides with (trifluoromethyl) trimethylsilane (Ruppert-Prakash reagent) has been developed. This method provides easy access to both N-alkyl - trifluoroacetylanilines and N-aryl - trifluoroacetylanilines in high yields. Cyclisation of N-aryl - trifluoroacetylanilines in trifluoroacetic acid gives 9- trifluoromethylacridines.
