1411774-47-4

Basic information

• Product Name: (S)-2-(4-methoxyphenyl)-6a,7,8,9-tetrahydro-5H-pyrido[3,2-e]pyrrolo[1,2-a][1,4]diazepine-6,11-dione
• Synonyms: (S)-2-(4-methoxyphenyl)-6a,7,8,9-tetrahydro-5H-pyrido[3,2-e]pyrrolo[1,2-a][1,4]diazepine-6,11-dione
• CAS NO: 1411774-47-4
• Molecular Weight: 323.351
• Mol File: 1411774-47-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-(4-methoxyphenyl)-6a,7,8,9-tetrahydro-5H-pyrido[3,2-e]pyrrolo[1,2-a][1,4]diazepine-6,11-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(4-methoxyphenyl)-6a,7,8,9-tetrahydro-5H-pyrido[3,2-e]pyrrolo[1,2-a][1,4]diazepine-6,11-dione(1411774-47-4)
• EPA Substance Registry System: (S)-2-(4-methoxyphenyl)-6a,7,8,9-tetrahydro-5H-pyrido[3,2-e]pyrrolo[1,2-a][1,4]diazepine-6,11-dione(1411774-47-4)

Safety Data

• Hazardous Substances Data: 1411774-47-4(Hazardous Substances Data)

Upstream product

• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 1335147-22-2 (S)-Methyl 1-(3-aminopicolinoyl)pyrrolidine-2-carboxylate 
• 1411774-30-5 (S)-methyl 1-(3-amino-6-bromopicolinoyl)pyrrolidine-2-carboxylate 
• 1462-86-8 3-amino-pyridine-2-carboxylic acid 
• 1411774-31-6 (S)-2-bromo-6a,7,8,9-tetrahydro-5H-pyrido[3,2-e]pyrrolo[1,2-a][1,4]diazepine-6,11-dione 
• 5720-07-0 4-methoxyphenylboronic acid 

Relevant articles and documents

A novel and convenient method for the synthesis of new derivatives of pyrido[3,2-e]pyrrolo[1,2-a][1,4]diazepine-6,11-dione

A novel methodology has been developed for the efficient synthesis of 1,4-pyridopyrrolodiazepine derivatives. The key reaction is the bromination under mild conditions by NBS of compounds resulting via peptide coupling of l-proline methyl ester with 3-aminopyridine-2-carboxylic acid 1, then intramolecular cyclization in the construction of 2-bromo-6a,7,8,9-tetrahydro- 5H-pyrido[3,2-e]pyrrolo[1,2-a][1,4]diazepine-6,11-dione 4. This latter is then engaged in cross-coupling reactions to generate 1,4-pyridopyrrolodiazepines derivatives 5a-m, 6a-i, 7, and 8a-c. This strategy provides an efficient method to access a library of compounds based on privileged substructures that are of great interest in drug discovery.