141196-74-9

Basic information

• Product Name: 1-trifluoroacetoxy-2,3,4,6-tetra-O-benzyl-α,β-D-glucopyranoside
• Synonyms: 1-trifluoroacetoxy-2,3,4,6-tetra-O-benzyl-α,β-D-glucopyranoside
• CAS NO: 141196-74-9
• Molecular Weight: 636.665
• Mol File: 141196-74-9.mol

Chemical Properties

• CAS DataBase Reference: 1-trifluoroacetoxy-2,3,4,6-tetra-O-benzyl-α,β-D-glucopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: 1-trifluoroacetoxy-2,3,4,6-tetra-O-benzyl-α,β-D-glucopyranoside(141196-74-9)
• EPA Substance Registry System: 1-trifluoroacetoxy-2,3,4,6-tetra-O-benzyl-α,β-D-glucopyranoside(141196-74-9)

Safety Data

• Hazardous Substances Data: 141196-74-9(Hazardous Substances Data)

Upstream product

• 604-69-3 β-D-glucose pentaacetate 
• 28244-94-2 p-tolyl-2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside 
• 1152-39-2 p-methylphenyl 1-thio-β-D-glucopyranoside 
• 4291-69-4 2,3,4,6-Tetra-O-benzyl-D-glucopyranose 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1585169-36-3 C₄₃H₄₅BrO₈ 
• 1585169-37-4 C₄₄H₄₆O₉ 
• 1585169-38-5 C₄₃H₄₄O₉ 
• 1585169-39-6 C₅₀H₅₀O₉ 
• 1585169-40-9 C₅₀H₅₀O₁₀ 
• 132817-37-9 1,2,3-Trimethoxy-4-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)benzene 
• 21794-66-1 1,6,7-trihydroxy-3-methoxylxanthone-2-C-β-D-glucopyranoside 
• 82300-67-2 1-deoxy-1-(C-2',4',6'-trimethoxyphenyl) 2,3,4,6-tetra-O-benzyl-β-D-glucopyranoside 

Relevant articles and documents

Total synthesis of mangiferin, homomangiferin, and neomangiferin

Total synthesis of mangiferin, homomangiferin, and neomangiferin, three C-glycosyl xanthone natural products with a wide spectrum of pharmacological effects, has been achieved starting from 2,3,4,6-tetra-O-benzyl-α/β-d-glucopyranose. The key steps involve a stereoselective Lewis acid promoted C-glycosylation of protected phloroglucinol with tetrabenzylglucopyranosyl acetate and a highly regioselective base-induced cyclization for the construction of the core xanthone skeleton.

Synthesis of 3,3′-Di- O -methyl ardimerin and exploration of its DNA binding properties

The 3,3′-di-O-methyl derivative (15) of the bis-C-aryl glycoside natural product ardimerin (1) has been synthesized in 11 steps from 2,3,4,6-tetrabenzylglucose (2) and 1,2,3-trimethoxybenzene (3). Key steps in the synthesis involve a Lewis acid mediated Friedel-Crafts type glycosylation and a Yamaguchi lactonization under Yonemitsu conditions. 3,3′-Di-O-methyl ardimerin aggregates in aqueous solutions at concentrations greater than 1 M, and both UV and fluorescence binding studies indicate that 15 has a low affinity for duplex DNA.

PLATINUM-CONTAINING COMPOUNDS EXHIBITING CYTOSTATIC ACTIVITY, SYNTHESIS AND METHODS OF USE

Platinum containing compounds exhibiting cytostatic activity, methods of synthesizing platinum-containing compounds exhibiting cytostatic activity pharmaceutical compositions comprising platinum containing compounds, and methods of using such compounds and compositions for treating cancer are disclosed.