141209-95-2

Basic information

• Product Name: 2-Oxazolidinone, 3-(1-oxo-3-phenyl-2-propenyl)-4-phenyl-
• CAS NO: 141209-95-2
• Molecular Formula: C18H15NO3
• Molecular Weight: 293.322
• Mol File: 141209-95-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 3-(1-oxo-3-phenyl-2-propenyl)-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 3-(1-oxo-3-phenyl-2-propenyl)-4-phenyl-(141209-95-2)
• EPA Substance Registry System: 2-Oxazolidinone, 3-(1-oxo-3-phenyl-2-propenyl)-4-phenyl-(141209-95-2)

Safety Data

• Hazardous Substances Data: 141209-95-2(Hazardous Substances Data)

Upstream product

• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 
• 102-92-1 Cinnamoyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 20989-17-7 (2S)-2-phenylglycinol 
• 2935-35-5 (S)-2-phenylglycine 

Downstream Products

• 189498-45-1 C₂₇H₂₆N₂O₃ 
• 189498-44-0 (S)-3-((3R,4S)-1-benzyl-4-phenyl-pyrrolidine-3-carbonyl)-4-phenyl-oxazolidin-2-one 
• 1245927-17-6 (4S,3'R,αS)-3-{3'-[N-benzyl-N-(α-methylbenzyl)amino]-3'-phenylpropanoyl}-4-phenyloxazolidin-2-one 
• 1245927-21-2 (4S,3'S,αR)-3-{3'-[N-benzyl-N-(α-methylbenzyl)amino]-3'-phenylpropanoyl}-4-phenyloxazolidin-2-one 
• 1245927-25-6 (4S,3'R)-3-[3'-(N,N-dibenzylamino)-3'-phenylpropanoyl]-4-phenyloxazolidin-2-one 
• 1396318-58-3 (1'R,2'S,3R,7a'R)-1-methyl-2-oxo-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizine]-2'-carboxylic acid 
• 1396318-49-2 (S)-3-((1'R,2'S,3R,7a'R)-1-methyl-2-oxo-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizin]-2'-ylcarbonyl)-4-phenyloxazolidin-2-one 
• 1396318-61-8 (1'R,2'S,3R,7a'R)-1-ethyl-2-oxo-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizine]-2'-carboxylic acid 
• 1396318-52-7 (S)-3-(1'R,2'S,3R,7a'R-1-ethyl-2-oxo-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizin]-2'-ylcarbonyl)-4-phenyloxazolidin-2-one 
• 1396318-54-9 (S)-3-((1'R,2'S,3R,7a'R)-5-nitro-1-ethyl-2-oxo-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizin]-2'-ylcarbonyl)-4-phenyloxazolidin-2-one 
• 1396318-59-4 (1'R,2'S,3R,7a'R)-1-methyl-5-bromo-2-oxo-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizine]-2'-carboxylic acid 
• 1396318-50-5 (S)-3-((1'R,2'S,3R,7a'R)-5-bromo-1-methyl-2-oxo-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizin]-2'-ylcarbonyl)-4-phenyloxazolidin-2-one 
• 1396318-57-2 (1'R,2'S,3R,7a'R)-5-nitro-2-oxo-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizine]-2'-carboxylic acid 
• 1396318-48-1 (S)-3-((1'R,2'S,3R,7a'R)-5-nitro-2-oxo-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizin]-2'-ylcarbonyl)-4-phenyloxazolidin-2-one 

Relevant articles and documents

Asymmetric synthesis of non-natural amino acid derivatives: (2R/3S) and (2S/3R) 2-(tert-butoxycarbonylamino)-3-cyclohexyl-3-phenyl propanoic acids

Highly conformationally-constrained novel α-amino acid derivatives ((2R/3S ) and (2S/3R )-2-(tert-butoxycarbonylamino)-3- cyclohexyl-3-phenylpropanoic acids) have been synthesised with high stereoselectivity (> 90% de) and in 36-37% overall yields. In the synthesis, Evans' auxiliary (4(R/S )-4-phenyl-oxzaolidin-2-one) was used to control the stereoselectivity via the key reactions of asymmetric Michael addition, azidation and catalytic hydrogenolysis.

Conjugate addition of aryl nucleophiles to α,β-unsaturated cinnamic acid derivatives containing Evans type chiral auxiliaries

Cinnamides containing oxazolidin-2-one type auxiliaries have been prepared. A novel pathway to chiral 4-aryl-6-methyl-3,4-dihydrocoumrines via the asymmetric conjugate addition of arylmagnesium bromides to these cinnamides is described.

Doubly diastereoselective conjugate addition of enantiopure lithium amides to enantiopure N-enoyl oxazolidin-2-ones: A mechanistic probe

The doubly diastereoselective conjugate addition of the antipodes of lithium N-benzyl-N-(α-methylbenzyl)amide to a range of enantiopure N-enoyl oxazolidin-2-ones has been used as a mechanistic probe to determine that the reactive conformation is the anti-s-cis form. The β-amino carbonyl products resulting from these conjugate addition reactions are useful templates for further elaboration into an α,β,α-pseudotripeptide.