141222-05-1

Basic information

• Product Name: Silane, [4-[(1E)-3-bromo-1-propenyl]phenoxy](1,1-dimethylethyl)dimethyl-
• CAS NO: 141222-05-1
• Molecular Formula: C15H23BrOSi
• Molecular Weight: 327.337
• Mol File: 141222-05-1.mol

Chemical Properties

• CAS DataBase Reference: Silane, [4-[(1E)-3-bromo-1-propenyl]phenoxy](1,1-dimethylethyl)dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [4-[(1E)-3-bromo-1-propenyl]phenoxy](1,1-dimethylethyl)dimethyl-(141222-05-1)
• EPA Substance Registry System: Silane, [4-[(1E)-3-bromo-1-propenyl]phenoxy](1,1-dimethylethyl)dimethyl-(141222-05-1)

Safety Data

• Hazardous Substances Data: 141222-05-1(Hazardous Substances Data)

Upstream product

• 381226-39-7 C₂₁H₃₆O₃Si₂ 
• 7400-08-0 p-Coumaric Acid 
• 125872-66-4 (E)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)prop-2-en-1-ol 

Downstream Products

• 556052-00-7 2-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-allyl}-2-methyl-malonic acid dimethyl ester 
• 556051-99-1 5-methyl-5-((2E)-3-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2-propenyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione 
• 556052-02-9 2-Methyl-2-{(E)-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-allyl}-malonic acid dimethyl ester 
• 556052-06-3 2-methyl-2-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-propyl}-malonic acid dimethyl ester 
• 556052-04-1 2-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-2-methyl-malonic acid dimethyl ester 
• 556052-05-2 2-[3-(4-hydroxy-phenyl)-propyl]-2-methyl-malonic acid dimethyl ester 
• 556052-01-8 2-[(E)-3-(4-Hydroxy-phenyl)-allyl]-2-methyl-malonic acid dimethyl ester 

Relevant articles and documents

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A systematic investigation was undertaken to determine the role of the P1' sidechain in a series of hydroxyethylene isostere based inhibitors of HIV-1 protease. Substitution and homologation of the benzyl P1' side chain of the Phe-Phe isostere based pseudo peptides 1 (L-682,679) and 2 (L-685,434) with various heteroalkyl groups leads to a series of extremely potent inhibitors of the enzyme. Several examples of the most potent inhibitors were very effective in an ex vivo cell based viral spread assay using human H9 T- lymphocytes and the IIIb isolate of HIV-1. Compound 19 is 120 times more potent than 1 and 16 times more potent than 2 in inhibiting the spread of infection in this assay.