1412494-57-5

Basic information

• Product Name: C₄₃H₅₈N₄O₈
• Synonyms: C₄₃H₅₈N₄O₈
• CAS NO: 1412494-57-5
• Molecular Weight: 758.956
• Mol File: 1412494-57-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₃H₅₈N₄O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₃H₅₈N₄O₈(1412494-57-5)
• EPA Substance Registry System: C₄₃H₅₈N₄O₈(1412494-57-5)

Safety Data

• Hazardous Substances Data: 1412494-57-5(Hazardous Substances Data)

Upstream product

• 1023970-58-2 (1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid allyl ester 
• 147221-33-8 1-methyl-1-phenylethyl 2,2,2-trichloroacetimidoate 
• 617-94-7 1-methyl-1-phenylethyl alcohol 
• 1412494-56-4 C₄₆H₆₂N₄O₈ 

Downstream Products

• 60239-18-1 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane 
• 617-94-7 1-methyl-1-phenylethyl alcohol 
• 1412494-58-6 C₅₂H₆₈N₆O₈ 

Relevant articles and documents

DOTA-tris(OPp ester) as a bifunctional prochelator for the preparation of DOTA-peptide conjugates

Peptides containing the chelator DOTA have gained importance for molecular imaging and therapy with radionuclides. However, all synthons described for the convergent solid phase synthesis of DOTA-peptide conjugates show windows of stability that are too narrow to allow a clean and convergent deprotection process. The synthesis of the new prochelator DOTA-tris(OPp ester) starting from cyclen is reported. Using this prochelator for the synthesis of several DOTA peptide conjugates revealed that its cleavage - in contrast to the cleavage of DOTA-tris(tBu ester) conjugates - does not require an extended deprotection time, and therefore results in clean and homogenous products.