141270-02-2Relevant articles and documents
Catechol diethers as selective PDE IV inhibitors
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, (2008/06/13)
This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDE IV and in the treatment of AIDS, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases. This invention also relates to pharmaceutical compositions comprising the compounds hereof
Catechol diether compounds as inhibitors of TNF release
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, (2008/06/13)
This invention relates to the use of catechol diether compounds for the manufacture of a medicament for use as an inhibitor of tumor necrosis factor (TNF). The catechol diether compounds are useful as inhibitors of TNP perseand in the treatment or alleviation of inflammatory conditionsor disease, including but not limited to rheumatoid arthritis, osteoarthritis, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and inflammatory bowel disease, sepsis, septic shock, tubercolosis, graft versus host disease and cachexis associated with AIDS or cancer.
Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogues
Ashton, Michael J.,Cook, David C.,Fenton, Garry,Karlsson, Jan-Anders,Palfreyman, Malcolm N.,et al.
, p. 1696 - 1703 (2007/10/02)
The syntheses and biological activities of a number of benzamide derivatives, designed from rolipram, which are selective inhibitors of cyclic AMP-specific phosphodiesterase (PDE IV), are described.The effects of changes to the alkoxy groups, amide linkag
Aryl substituted nitrogen heterocyclic antidepressants
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, (2008/06/13)
Antidepressant agents having the formula STR1 wherein R1 is a polycycloalkyl group; R2 is methyl or ethyl, X is O; and Y comprises a 5-membered heterocyclic ring having one or two nitrogens.
Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
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, (2008/06/13)
There are disclosed compounds of the formula STR1 wherein R is STR2 R1 is hydrogen, lower alkyl or STR3 a is 1-3; b is 1-3; c is 0-2; X, Y and Z are each, independently, a bond, O, S. or NH, with the proviso that if one of X or Y is O, S or NH, the other must be a bond; R2 is amino, loweralkylamino, arylamino, loweralkoxy or aryloxy; R3 is hydrogen, halo, hydroxy, lower alkoxy, aryloxy, loweralkanoyloxy, amino, lower alkylamino, arylamino or loweralkanoylamino; R4 and R5 are each, independently hydrogen or lower alkyl; m is 0-4; n is 1-4; and o is 1-4; and, which by virtue of their ability to selectively inhibit an isoenzyme of 3':5'-cyclic AMP phosphodiesterase located in pulmonary smooth muscle tissue and inflammatory cells, are bronchodilatory and antinflammatory and so are useful in the treatment of acute and chronic bronchial asthma and associated pathologies.
Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones
Saccomano,Vinick,Koe,Nielsen,Whalen,Meltz,Phillips,Thadieo,Jung,Chapin,Lebel,Russo,Helweg,Johnson Jr.,Ives,Williams
, p. 291 - 298 (2007/10/02)
The synthesis and biological properties of a novel series of selective calcium-independent phosphodiesterase inhibitors are described. These compounds also inhibit the specific binding of [3H]rolipram to rat brain membranes and exhibit efficacy
