141286-91-1

Basic information

• Product Name: (2,6-difluorophenoxy)acetic acid methyl ester
• Synonyms: (2,6-difluorophenoxy)acetic acid methyl ester
• CAS NO: 141286-91-1
• Molecular Weight: 202.158
• Mol File: 141286-91-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2,6-difluorophenoxy)acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2,6-difluorophenoxy)acetic acid methyl ester(141286-91-1)
• EPA Substance Registry System: (2,6-difluorophenoxy)acetic acid methyl ester(141286-91-1)

Safety Data

• Hazardous Substances Data: 141286-91-1(Hazardous Substances Data)

Upstream product

• 28177-48-2 2,6-difluorophenol 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 141286-78-4 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}thio)phenoxy]acetamide 
• 449811-11-4 6-(2,6-difluorophenoxy)-8-methyl-2-(methylthio)-pyrido[2,3-d]pyrimidin-7(8H)-one 
• 169298-45-7 methyl 4-<2-amino>ethylthio>-2,6-difluorophenoxyacetate 
• 1026657-72-6 methyl 4-<2-ethylthio>-2,6-difluorophenoxyacetate 
• 1026150-42-4 (4-{2-[(4-Chloro-benzenesulfonyl)-pyridin-2-ylmethyl-amino]-ethylsulfanyl}-2,6-difluoro-phenoxy)-acetic acid methyl ester 
• 1026659-62-0 (4-{2-[Benzyl-(4-chloro-benzenesulfonyl)-amino]-ethylsulfanyl}-2,6-difluoro-phenoxy)-acetic acid methyl ester 
• 1026848-78-1 (4-{2-[(4-Chloro-benzenesulfonyl)-pentyl-amino]-ethylsulfanyl}-2,6-difluoro-phenoxy)-acetic acid methyl ester 
• 169298-38-8 methyl 4-<2-(4-chlorophenylsulfonylamino)ethylsulfonyl>-2,6-difluorophenoxyacetate 
• 169298-37-7 {4-[2-(4-Chloro-benzenesulfonylamino)-ethanesulfinyl]-2,6-difluoro-phenoxy}-acetic acid methyl ester 
• 151389-32-1 methyl 4-<2-aminoethylthio>-2,6-difluorophenoxyacetate 

Relevant articles and documents

Synthesis and evaluation of novel fluorinated sulotroban-related sulfonamide derivatives as thromboxane A2 receptor antagonists

A series of sulotroban-related arylsulfonamide derivatives possessing a fluorinated phenoxyacetic acid moiety was synthesized and tested for TXA2 antagonizing ability on U-46619-induced platelet aggregation of rabbit platelet-rich plasma. Introduction of one or more fluorine atoms to the phenoxyacetic acid moiety increased this activity. The most potent compound among these compounds was 10c, which was 40-fold more potent (IC50 3.4 x 10-7 M) than sulotroban. 10c exhibited high activity (ID50 0.14 mg/kg) against a D-46619-induced acute thrombocytopenia model in mice when orally administrated. These findings and those of radioligand binding assays with various ligands showed 10c to be a potent and selective systemic TXA2 receptor antagonist.

In vivo AMPA receptors in the brain imaging method of primates, program, and screening method

This imaging method of AMPA receptors in the brain of primate organisms involves a step in which a substance which is administered to the primate organism and which selectively bonds to AMPA receptors in the brain of the primate organism and has a radiola

Sulfonamide derivatives

A sulfonamide derivative represented by the Formula: STR1 wherein A, B, X, Y, R, m and n are as defined in the specification, and a salt thereof have thromboxane A2 antagonism, therefore they are useful, for example, as blood platelet aggregati