28177-48-2

Basic information

• Product Name: 2,6-Difluorophenol
• Synonyms: 2,6-DIFLUOROPHENOL;Phenol, 2,6-difluoro-;2,6-Difluorophenol 98%;2,6-Difluorophenol98%;2,6-DIFLUOROPHENOL: 96.5%
• CAS NO: 28177-48-2
• Molecular Formula: C₆H₄F₂O
• Molecular Weight: 130.09
• EINECS: 248-884-9
• Product Categories: Fluoro-Aromatics;Aromatic Phenols;Fluorobenzene;Phenol&Thiophenol&Mercaptan;Fluorophenols;Organic Building Blocks;Oxygen Compounds;Phenols
• Mol File: 28177-48-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 38-41 °C(lit.)
• Boiling Point: 59-61 °C17 mm Hg(lit.)
• Flash Point: 138 °F
• Appearance: Colorless/Crystalline Low Melting Solid
• Density: 1,27 g/cm3
• Vapor Pressure: 2.11mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: 2-8°C
• Solubility: ethanol: soluble50mg/mL, clear, colorless to light yellow
• PKA: 7.45±0.10(Predicted)
• Water Solubility: Slightly soluble in water. Soluble in ethanol.
• BRN: 2043613
• CAS DataBase Reference: 2,6-Difluorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorophenol(28177-48-2)
• EPA Substance Registry System: 2,6-Difluorophenol(28177-48-2)

Safety Data

• Hazard Codes: F,Xi,Xn
• Statements: 11-36/37/38-20/21/22
• Safety Statements: 26-36/37/39
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• F: 10
• HazardClass: 4.1
• PackingGroup: II
• Hazardous Substances Data: 28177-48-2(Hazardous Substances Data)

Usage

Chemical Properties

colorless crystalline low melting solid

Uses

2,6-Difluorophenol undergoes oxidative polymerization in the presence of the Fe-N,N?-bis(salicylidene)ethylenediamine (salen) complex (catalyst) and hydrogen peroxide (oxidizing agent) to give poly(2,6-difluoro-1,4-phenylene oxide). It is also used as pharmaceutical intermediates.

InChI:InChI=1/C6H4F2O/c7-4-2-1-3-5(8)6(4)9/h1-3,9H

Upstream product

• 437-82-1 1,3-difluoro-2-methoxybenzene 
• 372-18-9 1,3-Difluorobenzene 
• 162101-25-9 2,6-difluorophenylboronic acid 
• 820220-75-5 2,6-difluorophenyl phenyl sulfate 
• 437-81-0 2,6-difluorobenzaldehyde 
• 2040-90-6 2-chloro-6-fluorophenol 
• 1228447-86-6 (2,6-difluorophenyl)(isopropoxy)dimethylsilane 
• 688-71-1 tri-n-propyl borate 
• 108-95-2 phenol 
• 5509-65-9 2,6-difluoroaniline 
• 18063-03-1 2,6-difluorobenzamide 
• 121602-93-5 3,4,5-trifluorobenzoic acid 

Downstream Products

• 363-45-1 2,6-difluorophenoxyacetic acid 
• 437-82-1 1,3-difluoro-2-methoxybenzene 
• 2362-50-7 thianthrene-5-oxide 
• 139656-65-8 5-(4-hydroxy-3,5-di-fluorophenyl)thianthreniumyl perchlorate 
• 92-85-3 Thianthrene 
• 113981-42-3 sodium 2,6-difluorophenolate 
• 84959-65-9 2,6-difluorobenzene-1,4-diol 
• 36914-78-0 2',6'-difluorophenyl acetate 
• 141286-91-1 (2,6-difluorophenoxy)acetic acid methyl ester 
• 100-02-7 4-nitro-phenol 
• 245075-54-1 1,3-difluoro-2-(2-propen-1-yloxy)benzene 
• 426830-83-3 2-(2,6-difluorophenoxy)ethanol 
• 14609-74-6 p-nitrophenolate 
• 20350-26-9 2,4-dinitrophenolate 

Relevant articles and documents

Synthesis method of fluorine-containing phenol structure compound

The invention discloses a synthesis method of a fluorine-containing phenol structure compound, and belongs to the technical field of chemical synthesis. Fluorine-containing benzoic acid is subjected to a one-pot reaction in a solvent under the action of alkali to obtain fluorine-containing phenate, and fluorine-containing phenol is obtained after acid regulation and dissociation. The synthesis method has the advantages of rich, cheap and easily available raw material structure, short synthesis steps, mild reaction conditions, simple and convenient operation, high synthesis yield, good productquality, wide application range and the like, and is suitable for simple and efficient synthesis of various high-value and high-purity fluorine-containing phenol compounds.

Method for preparing 2,6-difluoroindophenol acetate

The invention relates to a novel synthetic method for preparing 2,6-difluoroindophenol acetate, in particular to a production process for preparing the 2,6-difluoroindophenol acetate successively by virtue of six reaction steps of industrialized product 2,6-difluorobenzamide serving as a raw material, i.e. Hofmann degradation reaction, diazotization and direct hydrolysis, nitrification with concentrated nitric acid, catalytic hydrogenation reduction with palladium on carbon, diazotization and phenol coupling reaction and esterification under the condition of acetic anhydride and various corresponding process conditions. The method has the beneficial effects that the industrialized product 2,6-difluorobenzamide is used as the raw material, the raw material is easy to obtain, the price is low, and the reaction condition is mild and environmentally friendly. The invention provides a novel efficient way for producing the 2,6-difluoroindophenol acetate in an industrialization manner.

Quinolinone compound and application thereof in drugs

The invention relates to a quinolinone compound and application thereof in drugs, particularly relates to a novel quinolinone compound, a pharmaceutical composition thereof and use of the compound or the pharmaceutical composition in preparing drugs. The drug is used for protecting, disposing, treating or alleviating HIF-related and/or EPO-related diseases of patients, wherein the HIF-related and/or EPO-related diseases comprise anemia, vascular diseases, regional myocardial ischaemia, metabolic disturbance, wound healing and the like.