28177-48-2

Usage

Uses

Used in Polymer Synthesis:
2,6-Difluorophenol is used as a monomer for the production of poly(2,6-difluoro-1,4-phenylene oxide) through oxidative polymerization. This process involves the use of the Fe-N,N'-bis(salicylidene)ethylenediamine (salen) complex as a catalyst and hydrogen peroxide as an oxidizing agent. The resulting polymer has potential applications in various fields due to its enhanced properties.
Used in Pharmaceutical Industry:
2,6-Difluorophenol is used as a pharmaceutical intermediate, playing a crucial role in the synthesis of various drugs and medications. Its unique chemical structure allows for the development of new compounds with potential therapeutic benefits.

InChI:InChI=1/C6H4F2O/c7-4-2-1-3-5(8)6(4)9/h1-3,9H

Upstream product

• 162101-25-9 2,6-difluorophenylboronic acid 
• 1228447-86-6 (2,6-difluorophenyl)(isopropoxy)dimethylsilane 
• 688-71-1 tri-n-propyl borate 
• 372-18-9 1,3-Difluorobenzene 
• 121602-93-5 3,4,5-trifluorobenzoic acid 
• 18063-03-1 2,6-difluorobenzamide 
• 5509-65-9 2,6-difluoroaniline 
• 108-95-2 phenol 
• 2040-90-6 2-chloro-6-fluorophenol 
• 437-81-0 2,6-difluorobenzaldehyde 
• 820220-75-5 2,6-difluorophenyl phenyl sulfate 
• 437-82-1 1,3-difluoro-2-methoxybenzene 

Downstream Products

• 437-82-1 1,3-difluoro-2-methoxybenzene 
• 117923-74-7 C₆⁽¹³⁾CH₆F₂O 
• 118276-06-5 3,5-difluoro-4-hydroxybenzaldehyde 
• 2362-50-7 thianthrene-5-oxide 
• 139656-65-8 5-(4-hydroxy-3,5-di-fluorophenyl)thianthreniumyl perchlorate 
• 92-85-3 Thianthrene 
• 113981-42-3 sodium 2,6-difluorophenolate 
• 84959-65-9 2,6-difluorobenzene-1,4-diol 
• 658-07-1 2,6-Difluoro-4-nitrophenol 
• 141286-91-1 (2,6-difluorophenoxy)acetic acid methyl ester 
• 100-02-7 4-nitro-phenol 
• 554-84-7 meta-nitrophenol 
• 36914-78-0 2',6'-difluorophenyl acetate 
• 610-78-6 3-nitro-4-chlorophenol 

Relevant academic research and scientific papers

Synthesis method of fluorine-containing phenol structure compound

The invention discloses a synthesis method of a fluorine-containing phenol structure compound, and belongs to the technical field of chemical synthesis. Fluorine-containing benzoic acid is subjected to a one-pot reaction in a solvent under the action of alkali to obtain fluorine-containing phenate, and fluorine-containing phenol is obtained after acid regulation and dissociation. The synthesis method has the advantages of rich, cheap and easily available raw material structure, short synthesis steps, mild reaction conditions, simple and convenient operation, high synthesis yield, good productquality, wide application range and the like, and is suitable for simple and efficient synthesis of various high-value and high-purity fluorine-containing phenol compounds.

A practical method for preparation of phenols from arylboronic acids catalyzed by iodopovidone in aqueous medium

A novel and efficient strategy for the ipso-hydroxylation of arylboronic acids to phenols has been developed using inexpensive, readily available, air-stable water-soluble povidone iodine as catalyst and aqueous hydrogen peroxide as oxidizing agent. The reactions were performed at room temperature under metal-, ligand- and base-free condition in a short reaction time. The corresponding substituted phenols were obtained in moderate to good yields by oxidative hydroxylation of arylboronic acids in aqueous medium.

A aqueous phase preparation 2, 6 - [...] method

The invention relates to a green preparation 2, 6 - [...] synthetic method, to industrial product is 2, 6 - difluoro-benzamide as the starting material, passes through the aqueous phase Huffman degradation reaction, the aqueous phase diazotisations directly after the hydrolysis, direct concentrated nitric acid nitration, the iron powder reduces the aqueous phase, the aqueous phase with the aqueous phase to diazotization coupling reaction of phenol, after five step process for preparing aqueous phase reactions 2, 6 - [...] production process and corresponding various process conditions. The beneficial effect of the present invention is: select industrialized product 2, 6 - difluoro-benzamide as the raw material, raw materials are easy, low cost, through the aqueous phase reaction and solvent-free reaction for the preparation of 2, 6 - [...], its mild reaction conditions and environmental, safety and high efficiency. The present invention provides a kind of environmental protection, model, high efficiency can be used for the industrial production of 2, 6 - [...] green synthetic pathway.

Method for preparing 2,6-difluoroindophenol acetate

The invention relates to a novel synthetic method for preparing 2,6-difluoroindophenol acetate, in particular to a production process for preparing the 2,6-difluoroindophenol acetate successively by virtue of six reaction steps of industrialized product 2,6-difluorobenzamide serving as a raw material, i.e. Hofmann degradation reaction, diazotization and direct hydrolysis, nitrification with concentrated nitric acid, catalytic hydrogenation reduction with palladium on carbon, diazotization and phenol coupling reaction and esterification under the condition of acetic anhydride and various corresponding process conditions. The method has the beneficial effects that the industrialized product 2,6-difluorobenzamide is used as the raw material, the raw material is easy to obtain, the price is low, and the reaction condition is mild and environmentally friendly. The invention provides a novel efficient way for producing the 2,6-difluoroindophenol acetate in an industrialization manner.

1-cyclopropyl-4-oxo-7-fluoro-8-methoxy -1,4-dihydro-quinoline-3-carboxylic acid synthesizing method

The invention discloses a synthesis method of 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method comprises the following reaction steps: reacting m-difluorophenyl with an organolithium reagent, reacting an obtained aryllithium intermediate with borate, quenching to obtain 2,6-difluorophenylboronic acid and 2,6-difluorophenylborate, reacting 2,6-difluorophenol obtained through oxidation with a methylating reagent, reacting the obtained 2,6-difluorophenylmethyl ether with the organolithium reagent, reacting the obtained corresponding aryllithium intermediate with carbon dioxide, reacting the obtained product with an acylchlorinating reagent to obtain 2,4-difluoro-3-methoxy benzoyl chloride, and performing cyclization, hydrolysis and the like to obtain the 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method has the advantages as follows: raw materials are easy to obtain; the yield in each step is high; the atom economy is high; the synthesis method is suitable for industrial application.

Quinolinone compound and application thereof in drugs

The invention relates to a quinolinone compound and application thereof in drugs, particularly relates to a novel quinolinone compound, a pharmaceutical composition thereof and use of the compound or the pharmaceutical composition in preparing drugs. The drug is used for protecting, disposing, treating or alleviating HIF-related and/or EPO-related diseases of patients, wherein the HIF-related and/or EPO-related diseases comprise anemia, vascular diseases, regional myocardial ischaemia, metabolic disturbance, wound healing and the like.

Process for preparing phenol fluoride by amine catalytic method

The invention relates to a process for preparing phenol fluoride by amine catalytic method and belongs to the technical field of chemical synthesis.The process comprises: adding phenol and a catalyst sequentially into a reactor for heating, introducing fluorine-nitrogen mixed gas into the reactor for reacting, purging with nitrogen after reacting to obtain crude phenol fluoride, charging purging gas and reaction tail gas sequentially into an activated carbon absorber and a solid sodium lime absorber for adsorption, discharging finally obtained non-condensable gas at a great height, rectifying and separating the crude phenol fluoride to obtain o-fluorophenol, p-fluorophenol, 2,4-difluorophenol and 2,6-difluorophenol.The problem that an existing preparation process has low product yield, high solvent consumption, high cost and environmental pollution is solved herein, the process has the advantages of material conversion completeness, little byproduct and low production cost, no additional solvent is added to maintain a certain temperature range, cost is saved, and solvent loss is reduced.

Trichlorophenyl formate: Highly reactive and easily accessible crystalline CO surrogate for palladium-catalyzed carbonylation of aryl/alkenyl halides and triflates

The high utility of 2,4,6-trichlorophenyl formate, a highly reactive and easily accessible crystalline CO surrogate, is demonstrated. The decarbonylation with NEt3 to generate CO proceeded rapidly at rt, thereby allowing external-CO-free Pd-catalyzed carbonylation of aryl/alkenyl halides and triflates. The high reactivity of the CO surrogate enabled carbonylation at rt and significantly reduced the quantities of formate to near-stoichiometric levels. The obtained trichlorophenyl esters can be readily converted to a variety of carboxylic acid derivatives in high yields.

Arylsilane oxidation - New routes to hydroxylated aromatics

An efficient route to hydroxylated aromatics has been developed, via the oxidation of aryl organosilanes under functional group-tolerant and relatively mild conditions, using sub-stoichiometric amounts of fluoride promoters.

Enzymatic Baeyer-Villiger oxidation of benzaldehydes

The selectivity of the chemical Baeyer-Villiger oxidation of benzaldehydes depends on steric and electronic factors, the type of oxidizing agent and the reaction conditions. Here we report on the enzymatic Baeyer-Villiger oxidation of fluorobenzaldehydes