1412887-75-2

Upstream product

• 554-84-7 meta-nitrophenol 
• 1640-39-7 2,3,3-trimethylindoleniune 
• 14134-81-7 1-ethyl-2,3,3-trimethylindolium iodide 
• 108-94-1 cyclohexanone 
• 61010-04-6 2-chloro-1-formyl-3-hydroxymethylenecyclohexene 
• 13331-27-6 m-nitrobenzene boronic acid 

Downstream Products

• 1412887-76-3 C₄₀H₄₆N₃O⁽¹⁺⁾*I^(1-) 

Relevant academic research and scientific papers

A highly selective turn-on near-infrared fluorescent probe for hydrogen sulfide detection and imaging in living cells

We have described a turn-on near-infrared fluorescent probe Cy-NO 2 based on nitro group reduction for intracellular H2S detection. The probe employs cyanine dye as a fluorophore, and is equipped with a nitro group as a fluorescent modulator. It is readily employed for assessing intracellular H2S level changes, and confocal imaging is achieved successfully.

Screening and investigation of a cyanine fluorescent probe for simultaneous sensing of glutathione and cysteine under single excitation

Here we report the synthesis and screening of Cy-3-NO2 that showed simultaneous fluorescence sensing ability towards glutathione and cysteine under single excitation, and its application in living cell imaging.

A Glutathione (GSH)-Responsive Near-Infrared (NIR) Theranostic Prodrug for Cancer Therapy and Imaging

To reduce the side effects of chemotherapy, nontoxic prodrugs activated by the tumor microenvironment are urgently required for use in cancer treatment. In this work, we developed prodrug 4 for tumor-targeting treatment and imaging of the anticancer drug release in vivo. Taking advantage of the high glutathione (GSH) concentration in cancer cells, the disulfide bond in prodrug 4 was cleaved, resulting in the release of an active anticancer drug and a near-infrared (NIR) fluorescence dye turn-on. Furthermore, contrast to the free anticancer drug, the prodrug exhibited higher cytotoxicity to hepatoma cells than that to normal HL-7702 cells. Thus, prodrug 4 is a promising platform for specific tumor-activatable drug delivery system, because of its favorable features of in situ and in vivo monitoring of the drug release and therapeutic efficacy.

Pyroptosis drug prodrug, preparation method thereof and pyroptosis drug

The invention discloses a pyroptosis drug prodrug, a preparation method thereof and a pyroptosis drug. The pyroptosis drug prodrug provided by the invention can cause mitochondria damage, release cytochrome c and activate Caspase3 to shear GSDME by targeting mitochondria, so that pyroptosis of cells occurs. The prodrug (NCyNH2) has selectivity to tumor cells, damage to normal cells is reduced, and the activation condition of the prodrug (NCyNH2) can be detected through recovery of self-fluorescence. After intratumor administration, the prodrug can effectively regulate the tumor immune microenvironment and activate T cell mediated anti-tumor immune response. The molecule has huge application prospects in the aspects of mitochondrial targeting, cell respiration inhibition, pyroptosis induction, tumor immune microenvironment improvement, T cell mediated anti-tumor immune response activation and the like.

HDAC and CTSL responsive diagnosis and treatment integrated material and preparation method and application thereof

The invention belongs to the technical field of biological medicine and fluorescence detection, and particularly relates to an HDAC and CTSL responsive diagnosis and treatment integrated material and a preparation method and application thereof. The HDAC and CTSL responsive diagnosis and treatment integrated material is prepared from an anti-tumor drug Cy-NH2 and provided with a large number of HDAC and CTSL specific response bonds, enzyme response is generated in tumor cells with high HDAC and CTSL expression to be broken, so that the anti-tumor drug Cy-NH2 is rapidly released into the tumor cells, and the advantage of targeted drug delivery is achieved; and in addition, Cy-NH2 can be used for imaging tumor cells under the excitation of a specific wavelength, and has huge clinical application potential.

Dimer prodrug and preparation method and application thereof

The present invention discloses a dimer prodrug and a preparation method and an application thereof. A structural formula of the dimer prodrug is shown as follows. The dimer prodrug has a dual fluorescence effect, quenches fluorescences of CyNH2 and DOX through ICT and FRET effects, well monitors an activation process of a drug, also reduces toxicity, also utilizes a synergistic effect of the CyNH2 and DOX, and can also enhance a treatment effect on tumors.