1412887-76-3Relevant articles and documents
Construction of a Near-Infrared Fluorescent Turn-On Probe for Selenol and Its Bioimaging Application in Living Animals
Chen, Hua,Dong, Baoli,Tang, Yonghe,Lin, Weiying
, p. 11696 - 11700 (2015)
As selenocysteine (Sec) carries out the majority of the functions of the various Se-containing species in vivo, it is of high importance to develop reliable and rapid assays with biocompatibility to detect Sec. Herein, an NIR fluorescent turn-on probe for highly selective detection of selenol was designed and synthesized. The probe exhibits large turn-on signal upon treatment with selenocysteine (R-SeH), and it was further demonstrated that the new NIR fluorescent probe can be employed to image selenol in living animals. Simply red: The first near-infrared (NIR) fluorescent turn-on probe for highly selective detection of selenol was designed and synthesized (see figure). The probe exhibits a large turn-on signal upon treatment with selenocysteine (R-SeH), and it has been further demonstrated that the new NIR fluorescent probe can be employed to image selenol in living animals.