1412897-07-4

Basic information

• Product Name: (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(p-tolyl)-4,5-dihydro isoxazole 2-oxide
• Synonyms: (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(p-tolyl)-4,5-dihydro isoxazole 2-oxide
• CAS NO: 1412897-07-4
• Molecular Weight: 393.394
• Mol File: 1412897-07-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(p-tolyl)-4,5-dihydro isoxazole 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(p-tolyl)-4,5-dihydro isoxazole 2-oxide(1412897-07-4)
• EPA Substance Registry System: (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(p-tolyl)-4,5-dihydro isoxazole 2-oxide(1412897-07-4)

Safety Data

• Hazardous Substances Data: 1412897-07-4(Hazardous Substances Data)

Upstream product

• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Relevant articles and documents

Asymmetric catalytic [4 + 1] annulations catalyzed by quinidine: Enantioselective synthesis of multi-functionalized isoxazoline N-oxides

A highly regio-, chemo-, diastereo- and enantioselective organocatalytic [4 + 1] annulation of 2-halo-1,3-dicarbonyl compounds with Morita-Baylis-Hillman adducts catalyzed by commercially available, low cost quinidine for the preparation of synthetically unique and medicinally multi-functionalized isoxazoline N-oxides with three stereogenic centers including adjacent quaternary and tertiary stereocenters has been developed. Notably, the unexpected product ethyl 2-((tert-butyldimethylsilyl)oxy)-2-(5,5-diacetyl-3- ((methylsulfonyl)oxy)-4-phenylisoxazolidin-3-yl)acetate (8) bearing a quaternary stereocenter and two tertiary stereocenters was obtained from the undocumented 5,5-diacetyl-3-(2-ethoxy-1-hydroxy-2-oxoethyl)-4-phenyl-4,5-dihydroisoxazole 2-oxide (4ba).