1412904-47-2Relevant academic research and scientific papers
Novel 4(3H)-quinazolinone analogs: Synthesis and anticonvulsant activity
El-Azab, Adel S.,Abdel-Hamide, Sami G.,Sayed-Ahmed, Mohamed M.,Hassan, Ghada S.,El-Hadiyah, Tariq M.,Al-Shabanah, Othman A.,Al-Deeb, Omar A.,El-Subbagh, Hussein I.
, p. 2815 - 2827 (2013/07/26)
A new series of quinazoline analogs was designed, synthesized, and evaluated for their anticonvulsant activity. Compounds 6, 12, 21, 36, 37, and 38 showed 70-100 % protection against PTZ-induced seizures acting as GABA A receptor agonists. Compound N-(3,4,5,6-tetrachloro-phthalimido)-2- [(3-phenyl-4-oxo-6-methyl-3H-quinazolin-2-yl)-thio]acetamide (12) representing the moderate active compounds and 2-[6-iodo-4-oxo-2-(thiophen-2-yl)-quinazolin- 3(4H)-yl]-isoindoline-1,3-dione (38) representing the remarkably active compounds in this stud, showed ED50 values of 457 and 251 mg/kg; TD50 values of 562 and 447 mg/kg; PI values of 1.22 and 1.78, LD 50 values of 1,288 and 1,380 mg/kg, and TI values of 2.82 and 5.50, respectively. Compound 38 proved to be almost twofold more active than the standard drug sodium valproate.
