1412905-10-2Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors
Rambabu, D.,Mulakayala, Naveen,Ismail,Ravi Kumar, K.,Kalle, Arunasree M.,Oruganti, Srinivas,Pal, Manojit,Pavan Kumar, G.,Mulakayala, Chaitanya,Kumar, Chitta Suresh,Basaveswara Rao, M. V.
, p. 6745 - 6749,5 (2012/12/12)
A series of novel N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide derivatives were synthesized via converting the readily available 4-hydroxy coumarin to the corresponding ethyl 2-(2-oxo-2H-chromen-4-yloxy)propanoate followed by hydrolysis and then reacting with different substituted amines. The molecular structures of two representative compounds, that is, 3 and 5l were confirmed by single crystal X-ray diffraction study. All the compounds synthesized were evaluated for their cyclooxygenase (COX) inhibiting properties in vitro. The compound 5i showed balanced selectivity towards COX-2 over COX-1 inhibition and good docking scores when docked into the COX-2 protein.
