1412905-91-9

Upstream product

• 5162-44-7 1-bromo-4-butene 
• 57946-61-9 4-(2,2,2,-trifluoroethoxy)aniline 

Downstream Products

• 1412905-93-1 N-But-3-enyl-N-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-acrylamide 
• 1412905-94-2 1-[4-(2,2,2-Trifluoro-ethoxy)-phenyl]-5,6-dihydro-1H-pyridin-2-one 
• 1412905-96-4 5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one 
• 1412905-95-3 2-benzyl-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one 
• 1412906-17-2 (3aR,7aS)-2-(2-Hydroxy-phenyl)-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one 
• 1412906-15-0 (3aR,7aS)-2-[2-(2,4-Dichloro-phenyl)-2-hydroxy-ethyl]-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one 
• 1412905-98-6 (3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridine-2-carboxylic acid tert-butyl ester 
• 1412906-13-8 N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide 

Relevant academic research and scientific papers

New Hexahydrocyclopentapyrrolone, Hexahydropyrrolopyrrolone, Octahydropyrrolopyridinone and Octahydropyridinone Compounds

The invention provides novel compounds having the general formula (I) wherein R1, R2, A, E, G and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful as inhibitors of hormone sensitive lipase (HSL) and may be used for the treatment of diabetes, metabolic syndrome, dyslipidemia, atherosclerosis, obesity, cardiovascular diseases, myocardial dysfunction, inflammation, non-alcoholic fatty liver disease or non-alcoholic steatohepatitis.

NEW HEXAHYDROCYCLOPENTAPYRROLONE, HEXAHYDROPYRROLOPYRROLONE, OCTAHYDROPYRROLOPYRIDINONE AND OCTAHYDROPYRIDINONE COMPOUNDS

The invention provides novel compounds having the general formula (I) wherein R1, R2, A, E, G and n are as described herein, compositions including the compounds and methods of using the compounds.