1412908-37-2

Basic information

• Product Name: N-trifluoroacetyl-(S)-phenylalanyl-(R)-(2-(tert-butyldimethylsilyloxy)methylallyl)glycyl-(S)-N-methyl-leucineanilide
• Synonyms: N-trifluoroacetyl-(S)-phenylalanyl-(R)-(2-(tert-butyldimethylsilyloxy)methylallyl)glycyl-(S)-N-methyl-leucineanilide
• CAS NO: 1412908-37-2
• Molecular Weight: 704.905
• Mol File: 1412908-37-2.mol

Chemical Properties

• CAS DataBase Reference: N-trifluoroacetyl-(S)-phenylalanyl-(R)-(2-(tert-butyldimethylsilyloxy)methylallyl)glycyl-(S)-N-methyl-leucineanilide(CAS DataBase Reference)
• NIST Chemistry Reference: N-trifluoroacetyl-(S)-phenylalanyl-(R)-(2-(tert-butyldimethylsilyloxy)methylallyl)glycyl-(S)-N-methyl-leucineanilide(1412908-37-2)
• EPA Substance Registry System: N-trifluoroacetyl-(S)-phenylalanyl-(R)-(2-(tert-butyldimethylsilyloxy)methylallyl)glycyl-(S)-N-methyl-leucineanilide(1412908-37-2)

Safety Data

• Hazardous Substances Data: 1412908-37-2(Hazardous Substances Data)

Upstream product

• 950584-19-7 2-(((tert-butyldimethylsilyl)oxy)methyl)allyl ethyl carbonate 
• 1412908-27-0 N-trifluoroacetyl-(S)-phenylalanyl-glycyl-(S)-N-methyl-leucineanilide 

Relevant articles and documents

Highly stereoselective modifications of peptides via Pd-catalyzed allylic alkylation of internal peptide amide enolates

Pd-catalyzed allylations are excellent tools for stereoselective peptide modifications, showing several advantages compared to normal alkylations. Reactions of internal peptide amide enolates with Pd-allyl complexes proceed not only with high yields of up to 86%, they show also high regio- and diastereoselectivities (88-99%), giving rise to the trans-configured products. Therefore, this protocol is a powerful synthetic tool for the synthesis of natural product and drug molecules.

Highly stereoselective modifications of peptides via Pd-catalyzed allylic alkylation of internal peptide amide enolates

Pd-catalyzed allylations are excellent tools for stereoselective peptide modifications, showing several advantages compared to normal alkylations. Reactions of internal peptide amide enolates with Pd-allyl complexes proceed not only with high yields of up to 86%, they show also high regio- and diastereoselectivities (88-99%), giving rise to the trans-configured products. Therefore, this protocol is a powerful synthetic tool for the synthesis of natural product and drug molecules. The Royal Society of Chemistry 2012.