1412909-01-3Relevant academic research and scientific papers
Palladium catalyzed one-pot sequential Suzuki cross-coupling-direct C-H functionalization of imidazo[1,2- a ]pyrazines
Gembus, Vincent,Bonfanti, Jean-Fran?ois,Querolle, Olivier,Jubault, Philippe,Levacher, Vincent,Hoarau, Christophe
supporting information, p. 6012 - 6015 (2013/02/25)
An efficient one-pot selective functionalization at C3/C6 of imidazo[1,2-a]pyrazines has been developed via a palladium-catalyzed sequential Suzuki-Miyaura cross-coupling/direct C-H arylation, vinylation, and benzylation. The procedure remains effective in the presence of a methyl thioether group at C8, which may in turn be successfully engaged in a cross-coupling method to afford 3,6,8-trisubstituted imidazo[1,2-a]pyrazines. This work paves the way for the design of biologically relevant compounds in an imidazo[1,2-a]pyrazine series.
