2043-21-2

Basic information

• Product Name: 3-ACRYLOYL-2-OXAZOLIDINONE
• Synonyms: 3-ACRYLOYL-2-OXAZOLIDINONE;Acryloyl-2-oxazolidinone;3-Acryloyloxazolidin-2-one
• CAS NO: 2043-21-2
• Molecular Formula: C₆H₇NO₃
• Molecular Weight: 141.12
• Mol File: 2043-21-2.mol

Chemical Properties

• Melting Point: 83 °C
• Boiling Point: 194.48 °C at 760 mmHg
• Flash Point: 71.419 °C
• Appearance: /
• Density: 1.281 g/cm³
• Vapor Pressure: 0.441mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Refrigerator
• PKA: -1.76±0.20(Predicted)
• CAS DataBase Reference: 3-ACRYLOYL-2-OXAZOLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACRYLOYL-2-OXAZOLIDINONE(2043-21-2)
• EPA Substance Registry System: 3-ACRYLOYL-2-OXAZOLIDINONE(2043-21-2)

Safety Data

• Hazardous Substances Data: 2043-21-2(Hazardous Substances Data)

Usage

Uses

Used in Polymer Production:
3-ACRYLOYL-2-OXAZOLIDINONE is used as a monomer for the production of polymers due to its reactivity and ability to undergo polymerization and cross-linking reactions, which are essential for creating a variety of polymers with different properties.
Used in Coating and Adhesive Manufacturing:
3-ACRYLOYL-2-OXAZOLIDINONE is used as a key component in the manufacturing of coatings and adhesives for its contribution to the formation of stable and durable polymer networks that enhance the performance of these products.
Used in Biomedical Applications:
3-ACRYLOYL-2-OXAZOLIDINONE is used as a material in drug delivery systems and tissue engineering due to its biocompatibility and the ability to form stable polymer networks, which can be tailored for specific medical applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-ACRYLOYL-2-OXAZOLIDINONE is used as a monomer for the synthesis of polymers that can be utilized in drug delivery systems, potentially improving the efficacy and targeting of therapeutic agents.
Used in Tissue Engineering:
3-ACRYLOYL-2-OXAZOLIDINONE is used as a component in the development of scaffolds for tissue engineering, where its properties can be leveraged to create supportive structures that promote cell growth and tissue regeneration.

InChI:InChI=1/C6H7NO3/c1-2-5(8)7-3-4-10-6(7)9/h2H,1,3-4H2

Upstream product

• 497-25-6 dimethylenecyclourethane 
• 2051-76-5 acrylic acid anhydride 
• 79-10-7 acrylic acid 
• 3282-30-2 pivaloyl chloride 
• 68641-49-6 bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride 
• 814-68-6 acryloyl chloride 
• 1274906-21-6 3-[3-(benzyloxy)prop-1-yn-1-yl]-1,3-oxazolidin-2-one 
• 15486-96-1 3-Bromopropionyl chloride 
• 625-36-5 2-chloropropionyl chloride 

Relevant articles and documents

P-Anisaldehyde-Photosensitized Sulfonylcyanation of Chiral Cyclobutenes: Enantioselective Access to Cyclic and Acyclic Systems Bearing All-Carbon Quaternary Stereocenters

The photosensitized p-Anisaldehyde-mediated addition of sulfonylcyanides onto the I -system of cyclobutenes is shown to afford highly functionalized cyclobutanes in high yields and diastereocontrol. The homochiral cyclobutene precursors are accessible on multigram scale in two steps through an asymmetric [2 + 2] cycloaddition/vinyl thioether reduction sequence. The enantiopure cyclobutylnitriles can be elaborated further through SmI2-mediated ring opening or converted into new enantiopure cyclobutenes through base-mediated sulfone elimination.

On the formation of seven-membered rings by arene-ynamide cyclization

Abstract: A Br?nsted acid-catalyzed selective arene-ynamide cyclization is described. This reaction proceeds via a keteniminium intermediate and enables the preparation of seven-membered ring enamide products. Mechanistic studies uncover an unusual product inhibition behavior. Graphical abstract: [Figure not available: see fulltext.].

Ibrutinib synthesis method

The invention provides an ibrutinib synthesis method and belongs to the field of medicine synthesis. The synthesis method includes the step that a compound M and a compound of formula I undergo acylation reaction in the presence of alkaline. The synthesis method is mild in reaction conditions, side reaction is less, obtained ibrutinib is high in yield, and the purity is 99.50 or above. A syntheticroute of the synthesis method is described as follows.

Asymmetric Diels-Alder Reaction of α,β-Unsaturated Oxazolidin-2-one Derivatives Catalyzed by a Chiral Fe(III)-Bipyridine Diol Complex

An asymmetric FeIII-bipyridine diol catalyzed Diels-Alder reaction of α,β-unsaturated oxazolidin-2-ones has been developed. Among various FeII/FeIII salts, Fe(ClO4)3·6H2O was selected as th

Gold-catalyzed rearrangement of propargylic tert-butyl carbonates

Diversely substituted 4-alkylidene-1,3-dioxolan-2-ones are efficiently synthesized by a gold(I)-catalyzed rearrangement of propargylic tert-butyl carbonates. The substrates are readily accessible and the transformation, which is performed under mild react

SuperQuat 5,5-dimethyl-4-iso-propyloxazolidin-2-one as a mimic of Evans 4-tert-butyloxazolidin-2-one

The incorporation of a gem-dimethyl group at the 5-position of a chiral oxazolidinone biases the conformation of the adjacent C(4)-stereodirecting group such that the gem-dimethyl-4-iso-propyl combination mimics a C(4)-tert-butyl group, providing higher levels of stereocontrol than a simple 4-iso-propyloxazolidinone. The generality of this principle is demonstrated with applications in stereoselective enolate alkylations, kinetic resolutions, Diels-Alder cycloadditions and Pd-catalysed asymmetric acetalisation reactions. The Royal Society of Chemistry 2006.

An entry to a chiral dihydropyrazole scaffold: Enantioselective [3 + 2] cycloaddition of nitrile imines

We have developed a versatile strategy to access dihydropyrazoles in highly enantioenriched form. Dipolar cycloaddition of electron-deficient acceptors and in situ-generated nitrile imines proceeds with high regio- and enantioselectivity using 10 mol % chiral Lewis acid catalyst. A variety of dihydropyrazoles that incorporate functionality for further manipulation have been prepared. Copyright

Organic polymers and novel polymerizable compound

Organic polymers having water contact angles of 20° or smaller, preferably 7° or smaller and equipped with both high wettability and high transparency. The organic polymers may contain as partial structures polar structures of about 3 debyes or higher in dipole moment and are available especially from polymerization of polymerizable compounds having alkylene(thio)urea structures.

2-OXAZOLIDINONES AND THEIR USE AS INHIBITORS OF ANIMAL CELL MOTILITY AND GROWTH

Cell motility and growth inhibitors, including compounds of the general structural formula (I), and use of the cell motility and cell growth inhibitors, and pharmaceutically acceptable salts, pro-drugs, and solvates thereof, as therapeutic agents, are disclosed.

DCC/DMAP-Mediated Coupling of Carboxylic Acids with Oxazolidinones and Thiazolidinethiones

Dicyclohexylcarbodiimide and catalytic dimethylaminopyridine were successfully used in the coupling of carboxylic acids with oxazolidinones and thiazolidinethiones. The acylated products were obtained in good yields.