1412974-75-4

Upstream product

• 1609034-44-7 methyl (1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate 
• 1412974-73-2 (1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid 
• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 
• 1187932-69-9 (R)-tert-butyl 3-(iodomethyl)pyrrolidine-1-carboxylate 
• 768-35-4 3-fluorophenylboronic acid 
• 1412977-28-6 tert butyl (R)-3-(3-fluorobenzyl)-pyrrolidine-1-carboxylate 
• 1335494-76-2 3-(R)-(3-fluorobenzyl)pyrrolidine 
• 1412977-25-3 (R)-1-ethyl-3-(3-fluorobenzyl)pyrrolidine 
• 1412977-23-1 2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzenesulfonyl chloride 
• 64241-01-6 methyl 2-amino-6-hydroxybenzoate 
• 1356113-52-4 methyl 2-(2,2-dimethylpropionylamino)-6-hydroxybenzoate 
• 1412976-28-3 methyl 2-(2,2-dimethylpropionylamino)-6-(prop-2-ynyloxy)benzoate 
• 1412976-26-1 methyl 7-(2,2-dimethylpropionylamino)-2H-chromene-8-carboxylate 

Relevant academic research and scientific papers

METHODS OF TREATING LIVER DISEASES

The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.

PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME

The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.