141305-40-0

Usage

Uses

Used in Pharmaceutical Research:
4-bromo-2-phenylthiazole is utilized as a building block in organic synthesis and pharmaceutical research for its potential to contribute to the development of new drugs. Its unique structure and properties make it a valuable component in the creation of novel therapeutic agents.
Used in Antimicrobial and Antifungal Applications:
4-broMo-2-phenylthiazole is recognized for its potential as an antimicrobial and antifungal agent, making it a candidate for use in applications that require the inhibition of microbial growth, such as in the development of antibiotics and antifungal medications.
Used in Bioimaging Studies:
4-bromo-2-phenylthiazole has been investigated for its potential as a fluorescent labeling agent, which is significant for its use in bioimaging studies. This application allows researchers to visualize and track biological processes at the molecular level, enhancing understanding of cellular and molecular mechanisms.
Used in Chemical Research:
In the broader field of chemical research, 4-bromo-2-phenylthiazole serves as a valuable compound for studying the properties and reactions of thiazole derivatives, contributing to the advancement of organic chemistry and the discovery of new chemical reactions and compounds.

Upstream product

• 591-51-5 phenyllithium 
• 4175-77-3 2,4-dibromo-1,3-thiazole 
• 53715-67-6 5-bromo-2-phenyl-1,3-thiazole 
• 98-80-6 phenylboronic acid 
• 2227-79-4 benzenecarbothioamide 
• 105361-77-1 2-phenyl-4,5-dibromo-thiazole 
• 1826-11-5 2-phenylthiazole 
• 827-45-2 2-phenylthiazol-4-one 
• 161265-03-8 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene 

Downstream Products

• 1826-14-8 2,4-diphenylthiazole 
• 113214-23-6 2-phenyl-4-(2-thienyl)-thiazole 
• 1092073-95-4 2-methylsulfanyl-4-(2-phenylthiazol-4-yl)-pyrimidine 
• 2362-68-7 4-(4′-methoxyphenyl)-2-phenylthiazole 
• 2521-25-7 4-(4-nitrophenyl)-2-phenylthiazole 
• 1393673-12-5 C₁₈H₁₂N₂S₂ 
• 1393673-22-7 C₃₆H₂₀N₄S₄ 
• 1826-11-5 2-phenylthiazole 

Relevant academic research and scientific papers

Synthesis of 2′-substituted 4-bromo-2,4′-bithiazoles by regioselective cross-coupling reactions

The synthesis of the title compounds (1) was achieved in two steps starting from readily available 2,4-dibromothiazole (2). In a regioselective Pd(O)-catalyzed cross-coupling step, compound 2 was converted into a variety of 2-substituted 4-bromothiazoles

TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE

The invention provides a variety of compounds having the structure of Formula I and uses of such compounds for treatment of various indications, including cancer as well as methods of treatment involving such compounds are also provided. The uses of the compounds may specifically include: bladder cancer, cholangiocarcinoma; colorectal cancer; diffuse large B-cell lymphoma (DLBC); liver cancer; ovarian cancer; thymoma; thyroid cancer; clear cell renal cell carcinoma (CCRCC); chromophobe renal cell carcinoma (ChRCC); prostate cancer; breast cancer; uterine cancer; pancreatic cancer; cervical cancer; uveal melanoma; acute myeloid leukemia (AML); head and neck cancer; small cell lung cancer (SCLC); lung adenocarcinoma sarcoma; mesothelioma; adenoid cystic carcinoma (ACC), sarcoma; testicular germ cell cancer; uterine cancer; pheochromocytoma and paraganglioma (PCPG); melanoma; glioma; glioblastoma multiforme; T-cell Acute Lymphoblastic Leukemia; T-cell Lympohoma, medulloblastoma; and neuroblastoma.

Composite tetraheteroarylenes and related higher cyclic oligomers of heteroarenes produced by palladium-catalyzed direct coupling

Substantial research interests have been focused on cyclic π-conjugated molecules owing to their unique chemical and physical properties. By constructing hybrid aromatic arrays within these cyclic systems, new series of composite macrocycles would be prov

NOVEL COMPOUND, PHOTOACID GENERATOR CONTAINING THE COMPOUND, AND PHOTOSENSITIVE RESIN COMPOSITION CONTAINING THE PHOTOACID GENERATOR

PROBLEM TO BE SOLVED: To provide a nonionic photoacid generator with high acid generation quantum yield. SOLUTION: The present invention provides a compound represented by formula (2) (where, ring Ar is a benzene ring, naphthalene ring, thiophene ring or

RADIATION DETECTION METHOD AND DEVICE, AND NOVEL COMPOUND USED THEREFOR

PROBLEM TO BE SOLVED: To provide a photochromic compound that is excellent in sensitivity to a low dosage radiation. SOLUTION: Provided is a compound represented by the formula 1. (In the formula, R1 to R11 each independently represent a hydrogen atom, an

A self-contained photoacid generator for super acid based on photochromic terarylene

A self-contained photoacid generator for super acid along with the photoinduced 6π-electrocyclization reaction of the terarylene backbone is demonstrated. The photoinitiated cationic polymerization of epoxy-monomers is achieved with an efficient photochem

Substituent effects on the photochromic properties of benzothiophene-based derivatives

Five diarylethene photochromic derivatives, the structures of which incorporate a central benzothiophene unit, a left-hand thiazole group, and a right-hand benzothiophene group, have been prepared. The compound with a thiazole unit with no substituent on the reaction-center carbon atom reveals an unprecedented transformation upon light irradiation. When the 4-position of thiazole is protected by a methyl group, the compounds show high photosensitivity and photochromic properties. In this case, light irradiation affords new compounds with [5]helicene structures featuring the highest redshifted absorption maxima reported to date.

METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

NaBH4-TMEDA and a palladium catalyst as efficient regio- and chemoselective system for the hydrodehalogenation of halogenated heterocycles

The pair NaBH4-TMEDA as hydride source and a palladium catalyst in THF prove to be an efficient system for the hydrodehalogenation of halogenated heterocycles with one or more heteroatoms. In general, Pd(OAc) 2-PPh3 rapidly hydrodehalogenates reactive halo-heterocycles such as bromo-pyridines, -quinolines, -thiophenes, -indoles, -imidazoles, etc., at room temperature in very good yields, whereas in most cases PdCl2(dppf) reduces less reactive halides such as chloro-pyridines, -quinolines, -pyrimidines and bromo-indoles, -benzofurans, etc. Moreover, PdCl2(tbpf) shows to be even more active removing the 2- and 5-chlorine from both thiophene and thiazole rings. The reaction conditions tolerate various functional groups, allowing highly chemoselective reactions in the presence of halide, ester, alkyne, alkene and nitrile substituents. Moreover, with a proper selection of the catalyst it is also possible to obtain a good control in the regioselective hydrodehalogenation of a variety of polyhalogenated substrates.

Agri-Horticultural Pest Control Compositions Comprising 4-(3-Butynyl)Aminopyrimidine Derivatives

Agri-horticultural pest control compositions having outstanding control effect on pests, in particular, agri-horticultural pests, which comprise as active ingredients one or more 4-(3-butynyl)aminopyrimidine derivatives represented by the general formula [I], namely, where R1 is typically selected from among: a) phenyl c) —SiR5R6R7 (R5, R6, and R7 which may be the same or different represent a linear or branched alkyl having 1-6 carbon atoms, a linear or branched haloalkyl having 1-3 carbon atoms which is substituted by one halogen atom, a linear or branched cyanoalkyl having 1-3 carbon atoms which is substituted by one cyano group, and phenyl); d) hydropgen atom; R2 typically represents a hydrogen atom; R3 typically represents a hydrogen atom; R4 represents a hydrogen atom and one or more agri-horticultural pest control compounds selected from among agri-horticultural antimicrobial compounds, say, multi-site contact active compouns, nucleic acids synthesis inhibitory active compounds, mitosis and cell divesion inhibitory active compounds, and/or agri-horticultural insecticidal, miticidal or nematicidal compounds, say, acetylcholinesterase inhibitors, GABA-gated chloride antagonists, and sodium channel modulators. Since the 4-(3-butynyl)aminopyrimidine derivatives and the existing antimicrobial active compounds and/or insecticidal active compounds are used in admixture, the 4-(3-butynyl)aminopyrimidine derivatives which are useful as pest control agents, particularly as agri-horticultural pest control agents, need be used in smaller amounts and yet their antimicrobial or insecticidal activity can be improved.