141306-83-4 Usage
Chemical class
Indole carboxylic acids
Structure
Methyl ester derivative of 5-chloro-3-(4-fluorophenyl)-1H-indole-2-carboxylic acid
Use
Development of pharmaceutical drugs
Therapeutic potential
Treatment of liver diseases, including non-alcoholic steatohepatitis (NASH) and primary biliary cholangitis
Mechanism of action
Potent and selective agonist of the farnesoid X receptor (FXR), which regulates bile acid metabolism, lipid metabolism, and inflammatory processes in the liver
Current status
Promising results in preclinical and early clinical studies, being further investigated for potential as a treatment for liver disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 141306-83-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,3,0 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 141306-83:
(8*1)+(7*4)+(6*1)+(5*3)+(4*0)+(3*6)+(2*8)+(1*3)=94
94 % 10 = 4
So 141306-83-4 is a valid CAS Registry Number.
141306-83-4Relevant academic research and scientific papers
Selective, Centrally Acting Serotonin 5-HT2 Antagonists. 2. Substituted 3-(4-Fluorophenyl)-1H-indoles
Andersen, Kim,Perregaard, Jens,Arnt, Joern,Nielsen, Joern Bay,Begtrup, Mikael
, p. 4823 - 4831 (2007/10/02)
A series of 3-(4-fluorophenyl)-1H-indoles substituted in the 1-position with 4-piperidinyl, 1,2,3,6-tetrahydro-4-pyridinyl, and 4-piperazinyl was synthesized. By variation of the substituents in the benzene part of the indole nucleus in 1-2-4-3-(4-fluo
