141306-08-3

Usage

Structure

An indole derivative with a chloro and fluorophenyl substituent

Usage

A key intermediate in organic synthesis and pharmaceutical research for the synthesis of biologically active molecules

Value

A valuable building block for the preparation of drugs and agrochemicals due to its unique structure and chemical reactivity

Pharmacological activities

Anti-inflammatory and anticancer properties, making it an interesting target for further studies and drug development.

Upstream product

• 1028305-80-7 5-Chloro-3-(4-fluoro-phenyl)-1H-indole-2-carboxylic acid 
• 122255-02-1 methyl 2-(4-fluorobenzyl)-3-oxobutanoate 
• 141306-83-4 methyl 5-chloro-3-(4-fluorophenyl)-1H-indole-2-carboxylate 
• 1477-50-5 Indole-2-carboxylic acid 
• 17422-32-1 5-chloro-1H-indole 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 141306-19-6 5-chloro-3-(4-fluorophenyl)-1-(4-pyridinyl)-1H-indole 
• 141306-21-0 5-chloro-3-(4-fluorophenyl)-1-(4-piperidinyl)-1H-indole 

Relevant academic research and scientific papers

Synthesis and antimycobacterial activity of 3-phenyl-1h-indoles

Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in the last year. Herein, a series of 20 1H-indoles were synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (Mtb) g

3-ARYLINDOLE COMPOUNDS

3-Arylindole or 3-arylindazole derivatives having formula: STR1 wherein Ar is optionally substituted phenyl or a heteroaromatic group; R. sup.1-R 4 are independently selected from hydrogen, halogen, alkyl, alkoxy, hydroxy, nitro, alkylthio, alkylsulphonyl

Selective, Centrally Acting Serotonin 5-HT2 Antagonists. 2. Substituted 3-(4-Fluorophenyl)-1H-indoles

A series of 3-(4-fluorophenyl)-1H-indoles substituted in the 1-position with 4-piperidinyl, 1,2,3,6-tetrahydro-4-pyridinyl, and 4-piperazinyl was synthesized. By variation of the substituents in the benzene part of the indole nucleus in 1-2-4-3-(4-fluo