141333-59-7Relevant academic research and scientific papers
Phenylpyridyl compounds for inhibiting phosphodiesterase IV and methods of using same
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, (2008/06/13)
PCT No. PCT/US96/00519 Sec. 371 Date Nov. 13, 1997 Sec. 102(e) Date Nov. 13, 1997 PCT Filed Jan. 11, 1996 PCT Pub. No. WO96/21435 PCT Pub. Date Jul. 18, 1996Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improve
Novel cyclic compounds as potent phosphodiesterase 4 inhibitors
He, Wei,Huang, Fu-Chih,Hanney, Barbara,Souness, John,Miller, Bruce,Liang, Guyan,Mason, Jon,Djuric, Stevan
, p. 4216 - 4223 (2007/10/03)
The synthesis and biological activity of a novel series of 2,2- disubstituted indan-1,3-dione-based PDE4 inhibitors are described. This structurally unique class of PDE4 inhibitors is markedly different from the known PDE4 inhibitors such as RP 73401 (2) and CDP 840 (3). Structure- activity relationship (SAR) studies led to the identification of inhibitors with nanomolar potency and oral activity in a murine endotoxemia model for TNF-α inhibition. Unlike other classical PDE4 inhibitors, several analogues were found to be nonemetic in a canine emesis model at intravenous doses of up to 3 mg/kg.
Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
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, (2008/06/13)
Rolipram-based PDE IV inhibitors containing phenyl- or benzyl-substituted moieties of the formula: STR1 wherein X1 and X2 may be the same or different and each is O or S; R1 is selected from the group consisting of hydroge
