203439-58-1

Basic information

• Product Name: Acetic acid 4-[2-(3-cyclopentyloxy-4-methoxy-phenyl)-1,3-dioxo-indan-2-ylmethyl]-phenyl ester
• Synonyms: Acetic acid 4-[2-(3-cyclopentyloxy-4-methoxy-phenyl)-1,3-dioxo-indan-2-ylmethyl]-phenyl ester
• CAS NO: 203439-58-1
• Molecular Weight: 484.549
• Mol File: 203439-58-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid 4-[2-(3-cyclopentyloxy-4-methoxy-phenyl)-1,3-dioxo-indan-2-ylmethyl]-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 4-[2-(3-cyclopentyloxy-4-methoxy-phenyl)-1,3-dioxo-indan-2-ylmethyl]-phenyl ester(203439-58-1)
• EPA Substance Registry System: Acetic acid 4-[2-(3-cyclopentyloxy-4-methoxy-phenyl)-1,3-dioxo-indan-2-ylmethyl]-phenyl ester(203439-58-1)

Safety Data

• Hazardous Substances Data: 203439-58-1(Hazardous Substances Data)

Upstream product

• 141333-59-7 2-(3-cyclopentyloxy-4-methoxyphenyl)acetic acid 
• 133332-37-3 methyl 2-(3-cyclopentoxy-4-methoxyphenyl)ethanoate 
• 15964-81-5 methyl 3-hydroxy-4-methoxyphenylacetate 
• 1131-94-8 homoisovanillic acid 
• 85-44-9 phthalic anhydride 
• 39720-27-9 4-acetoxybenzyl chloride 
• 203441-50-3 2-(3-Cyclopentyloxy-4-methoxy-phenyl)-indan-1,3-dione 

Relevant articles and documents

Novel cyclic compounds as potent phosphodiesterase 4 inhibitors

The synthesis and biological activity of a novel series of 2,2- disubstituted indan-1,3-dione-based PDE4 inhibitors are described. This structurally unique class of PDE4 inhibitors is markedly different from the known PDE4 inhibitors such as RP 73401 (2) and CDP 840 (3). Structure- activity relationship (SAR) studies led to the identification of inhibitors with nanomolar potency and oral activity in a murine endotoxemia model for TNF-α inhibition. Unlike other classical PDE4 inhibitors, several analogues were found to be nonemetic in a canine emesis model at intravenous doses of up to 3 mg/kg.