141367-38-6Relevant articles and documents
Synthesis and adrenergic properties of new duplicated analogs of methoxamine
Perez,Rosell,Mauleon,Carganico
, p. 1155 - 1166 (2007/10/02)
New duplicated analogs of the α1-selective agonist methoxamine and of its cyclic derivative 5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthylamine have been synthesized and tested for their adrenergic properties. All the compounds prepared, presenting a polymethylene spacer of varying length between two units of the active structure, turned out to be completely devoid of any α-stimulating activity. Surprisingly, some of them showed a marked β-adrenergic agonistic effect, being the most interesting compound active at nanomolar concentration.