141367-35-3

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Downstream Products

• 56979-58-9 2-(2,5-dimethoxyphenyl)-2-hydroxyacetonitrile 
• 60407-53-6 1-(2',5'-dimethoxyphenyl)-2-aminoethanol hydrochloride 
• 141381-40-0 N,N'-bis<2-hydroxy-2-(2,5-dimethoxyphenyl)ethyl>-hexamethylenediamine 
• 141367-31-9 N,N'-bis<2-hydroxy-2-(2,5-dimethoxyphenyl)ethyl>-tetramethylenediamine 
• 141367-37-5 5,5'-bis(2,5-dimethoxyphenyl)-3,3'-hexamethylenedi(oxazolidin-2-one) 
• 141367-38-6 5,5'-bis(2,5-dimethoxyphenyl)-3,3'-tetramethylenedi(oxazolidin-2-one) 
• 141367-36-4 5-(2,5-dimethoxyphenyl)oxazolidin-2-one 
• 100947-36-2 5-(2,5-Dimethoxy-phenyl)-oxazolidine-2,4-dione 
• 3600-87-1 desglymidodrine 

Relevant academic research and scientific papers

Solvent-free cyanosilylation of aromatic and heteroaryl aldehydes catalyzed by a cationic iron N-heterocyclic carbene complex at ambient temperature under UV irradiation

The cyanosilylation of aromatic aldehydes and heteroaryl aldehydes with trimethylsilyl cyanide (TMSCN) is efficiently catalyzed by an iron complex of the type {[3-isopropyl-1-(1R-phenylethyl)imidazol-2-ylidene]Fe(CO)2}I (3) in presence of UV li

A cationic aluminium complex: An efficient mononuclear main-group catalyst for the cyanosilylation of carbonyl compounds

A structurally characterized cationic aluminium complex [(AT)Al(DMAP)]+[OTf]- (3) stabilized through a relatively nonbulky aminotroponate (AT) ligand is reported (DMAP = 4-(dimethylamino)pyridine). This compound was found to work as

Asymmetric synthesis of both enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1-methyletyhoxy)phenyl]ethanol

Both enantiomers of 2-(dimethylamino)-1-[3- methoxy-2-(1-methylethoxy)phenyl]ethanol were synthetized by a stereoselective route and evaluated in vitro for their uroselectivity in comparison with other α1-adrenoceptor agonists. The most potent enantiomer was structurally characterized by X-ray crystallographic analysis.

Photoremovable Protecting Groups for Phosphorylation of Chiral Alcohols. Asymmetric Synthesis of Phosphotriesters of (-)-3',5'-Dimethoxybenzoin

Procedures have been developed for the preparation of dimethoxybenzoinyl (DMB) phosphate triesters that can be deprotected photochemically.These compounds can be useful in light-directed synthesis and caging.The photochemistry of a wide variety of fluorine-, oxygen-, and nitrogen-substituted benzoin acetates was examined to determine the substitution pattern in the nonacylated aromatic ring producing optimum chemical yields.Two groups, 2',3'-dimethoxybenzoin and 3',5'-dimethoxybenzoin, were found to give the highest yields of the benzofuran product and were further developed for the photochemical deprotection of phosphate esters.These reactions could not be quenched, suggesting a singlet photosolvolysis mechanism.An asymmetric synthesis of 3',5'-dimethoxybenzoin via the benzaldehyde cyanohydrin was developed that minimizes the number of diastereomers formed in the phosphorylation of chiral alcohols.A phosphoramidite reagent for the derivatization of alcohols was prepared and used to produce scalemic dimethoxybenzoinyl phosphate esters from pantolactone and glycerol, serine, and tyrosine derivatives.These compounds were deprotected photochemically to produce the phosphodiesters in high yield.

Synthesis and adrenergic properties of new duplicated analogs of methoxamine

New duplicated analogs of the α1-selective agonist methoxamine and of its cyclic derivative 5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthylamine have been synthesized and tested for their adrenergic properties. All the compounds prepared, presenting a polymethylene spacer of varying length between two units of the active structure, turned out to be completely devoid of any α-stimulating activity. Surprisingly, some of them showed a marked β-adrenergic agonistic effect, being the most interesting compound active at nanomolar concentration.

Enzymatic Preparation of Optically Active Cyanohydrin Acetates

A series of cyanohydrin acetates (1)-(47) of widely varying structures, potential chiral building blocks for numerous synthetic applications, has been prepared in good chemical and often high optical yields by enzymatic hydrolysis of their racemic acetates in the presence of an ester hydrolase from Pseudomonas sp.