1413876-10-4

Basic information

• Product Name: C₈₈H₁₄₂N₂₈O₃₅S₃
• CAS NO: 1413876-10-4
• Molecular Weight: 2248.46
• Mol File: 1413876-10-4.mol

Chemical Properties

• CAS DataBase Reference: C₈₈H₁₄₂N₂₈O₃₅S₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₈₈H₁₄₂N₂₈O₃₅S₃(1413876-10-4)
• EPA Substance Registry System: C₈₈H₁₄₂N₂₈O₃₅S₃(1413876-10-4)

Safety Data

• Hazardous Substances Data: 1413876-10-4(Hazardous Substances Data)

Upstream product

• 144-48-9 iodacetamide 

Relevant articles and documents

Peptide peak intensities enhanced by cysteine modifiers and MALDI TOF MS

Two cysteine-specific modifiers we reported previously, N-ethyl maleimide (NEM) and iodoacetanilide (IAA), have been applied to the labeling of cysteine residues of peptides for the purpose of examining the enhancement of ionization efficiencies in combination with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS). The peak intensities of the peptides as a result of modification with these modifiers were compared with the peak intensities of peptides modified with a commercially available cysteine-specific modifier, iodoacetamide (IA). Our experiments show significant enhancement in the peak intensities of three cysteine-containing synthetic peptides modified with IAA compared to those modified with IA. The results showed a 4.5-6-fold increase as a result of modification with IAA compared to modification with IA. Furthermore, it was found that IAA modification also significantly enhanced the peak intensities of many peptides of a commercially available proteins, bovine serum albumin (BSA), compared to those modified with IA. This significant enhancement helped identify a greater number of peptides of these proteins, leading to a higher sequence coverage with greater confidence scores in identification of proteins with the use of IAA.