141389-23-3

Upstream product

• 141389-25-5 6-imino-4-oxo-3-phenyl-6H-pyrido[2,1-a]isoindole-1-carboxylic acid 
• 141389-22-2 benzyl 4,6-dihydro-4-oxo-3-phenylpyrido[2,1-a]isoindole-1-carboxylate 
• 480-91-1 oxisoindole 
• 110925-01-4 methyl 4-oxo-3-phenyl-4H-pyrido[2,1-a]phthalazine-1-carboxylate 
• 141405-51-8 C₁₇H₁₁NO₃ 
• 141388-83-2 methyl 4,6-dihydro-4-oxo-3-phenyl-4H-pyrido[2,1-a]isoindole-1-carboxylate 

Downstream Products

• 141388-89-8 cis-4-[(4,6-dihydro-4-oxo-3-phenylpyrido-[2,1-a]isoindol-1-yl)carbonyl]-2,6-dimethylmorpholine 

Relevant academic research and scientific papers

SYNTHESIS OF 4,6-DIHYDRO-4-OXOPYRIDOISOINDOLES AND 4,6-DIHYDRO-6-OXOTHIENOPYRROLOPYRIDINES

Tricyclic pyridones (3) which are important intermediates for the preparation of potent benzodiazepine receptor ligands were obtained by different chemical routes.Key reaction in the so far optimal synthesis of 3a is the base catalyzed ring contraction reaction of 2 to intermediate (13).Under similar reaction conditions, however, thiophene derivative (14) yielded instead of the analogous acid (16), the nitrile (15).In two additional steps the final product (3b) was obtained in good yield.

Tricyclic pyridone derivatives

The novel pyridone derivatives of the formula STR1 wherein Ra is hydrogen or halogen, Rb is --NR2 R3 wherein R2 and R3 taken together with the nitrogen atom to which they are attached is a 1-azetidinyl, 1-pyrrol