1413996-17-4

Basic information

• Product Name: (E)-4-(benzyloxyimino)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
• Synonyms: (E)-4-(benzyloxyimino)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
• CAS NO: 1413996-17-4
• Molecular Weight: 269.303
• Mol File: 1413996-17-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-4-(benzyloxyimino)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(benzyloxyimino)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one(1413996-17-4)
• EPA Substance Registry System: (E)-4-(benzyloxyimino)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one(1413996-17-4)

Safety Data

• Hazardous Substances Data: 1413996-17-4(Hazardous Substances Data)

Upstream product

• 622-33-3 N-benzyloxyamine 
• 72908-87-3 aldisin 
• 129053-84-5 3-<(1H-pyrrole-2-carbonyl)amino>propionic acid 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 129053-83-4 3-[(1H-pyrrole-2-carbonyl)-amino]-propionic acid ethyl ester 

Relevant articles and documents

Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine

The tetrahydroazepinone pharmacophore is a component of many interesting compounds, including several marine natural products, with anti-cancer properties. The synthesis and biological evaluation of a novel series of pyrroloazepinone and indoloazepinone oximes is reported. These compounds showed promising growth inhibition activity against four human cancer cell lines but did not significantly inhibit the cell cycle regulator cyclin dependent kinase 2. The most active compounds in this series displayed improved anti-proliferative activity over the related synthetic indoloazepine kenpaullone. The structure activity relationships exhibited by the azepinone pharmacophore suggests several novel lead compounds for anti-cancer drug discovery.