141404-09-3

Basic information

• Product Name: (3R,5R)-3,5-bis<(tert-butyldimethylsilyl)oxy>-4-<(trimethylsilyl)oxy>cyclohexanone
• Synonyms: (3R,5R)-3,5-bis<(tert-butyldimethylsilyl)oxy>-4-<(trimethylsilyl)oxy>cyclohexanone
• CAS NO: 141404-09-3
• Molecular Weight: 446.85
• Mol File: 141404-09-3.mol

Chemical Properties

• CAS DataBase Reference: (3R,5R)-3,5-bis<(tert-butyldimethylsilyl)oxy>-4-<(trimethylsilyl)oxy>cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5R)-3,5-bis<(tert-butyldimethylsilyl)oxy>-4-<(trimethylsilyl)oxy>cyclohexanone(141404-09-3)
• EPA Substance Registry System: (3R,5R)-3,5-bis<(tert-butyldimethylsilyl)oxy>-4-<(trimethylsilyl)oxy>cyclohexanone(141404-09-3)

Safety Data

• Hazardous Substances Data: 141404-09-3(Hazardous Substances Data)

Upstream product

• 6087-40-7 (2R,3S,4R,6S)-3,4-diacetoxy-2-(acetoxymethyl)-6-methoxytetrahydro-2H-pyran 
• 506423-07-0 (1R,2R,3R,5S)-2,3-Bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-cyclohexanol 
• 506423-05-8 (2S,3R,5R)-2,3-Bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-cyclohexanone 
• 506423-10-5 (3R,5R)-3,4,5-Tris-benzyloxy-cyclohexanol 
• 95639-53-5 3(R),5(R)-trihydroxycyclohexanone 
• 6752-48-3 methyl 4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside 
• 13145-22-7 methyl 2-deoxy-α-D-glucopyranoside 
• 189758-77-8 methyl 3,4-di-O-benzyl-2-deoxy-5-methylene-α-D-xylopyranoside 
• 725268-38-2 (2S,3R)-2,3-Bis-benzyloxy-5-hydroxy-cyclohexanone 
• 175844-98-1 methyl 3,4-di-O-benzyl-2,6-dideoxy-6-iodo-α-D-glucopyranoside 
• 81308-73-8 (3R,5R)-3,4,5-Tris-benzyloxy-cyclohexanone 
• 119943-96-3 Methyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-α-D-arabino-hexopyranoside 
• 145149-85-5 Methyl 3,4-di-O-benzyl-2-deoxy-α-D-arabino-hexopyranoside 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 681830-91-1 3,5-bis-[(tert-butyldimethylsilyl)oxy]-4-[(trimethylsilyl)oxy]cyclohexanol benzyl ether 
• 681830-92-2 2,6-bis-[(tert-butyldimethylsilyl)oxy]-4-(benzyloxy)cyclohexanol 
• 681433-62-5 (2R,6R)-2,6-bis-[(tert-butyldimethylsilyl)oxy]-4-(benzyloxy)cyclohexanone 
• 681433-95-4 (3R,5R)-[3,5-bis-[(tert-butyldimethylsilyl)oxy]-4-[2-(tert-butyldimethylsilyl)oxyethyl]cyclohexylidene]ethyldiphenylphoshine oxide 
• 681433-93-2 (3R,5R)-[3,5-bis-[(tert-butyldimethylsilyl)oxy]-4-[2-(tert-butyldimethylsilyl)oxyethyl]cyclohexylidene]acetic acid methyl ester 
• 681433-94-3 (3R,5R)-[3,5-bis-[(tert-butyldimethylsilyl)oxy]-4-[2-(tert-butyldimethylsilyl)oxyethyl]cyclohexylidene]ethanol 
• 681433-92-1 3,5-bis-[(tert-butyldimethylsilyl)oxy]-4-[(tert-butyldimethylsilyl)oxyethylidene]cyclohexanol 
• 159685-66-2 <(aR^*,3'R,5'R)-3',5'-bis<(tert-butyldimethylsilyl)oxy>-4'-<(trimethylsilyl)oxy>cyclohexylidene>acetic acid methyl ester 
• 159685-66-2 <(aS^*,3'R,5'R)-3',5'-bis<(tert-butyldimethylsilyl)oxy>-4'-<(trimethylsilyl)oxy>cyclohexylidene>acetic acid methyl ester 
• 160399-72-4 <(aS^*,3'R,5'R)-3',5'-bis<(tert-butyldimethylsilyl)oxy>-4'-hydroxycyclohexylidene>acetic acid methyl ester 
• 160399-72-4 <(aR^*,3'R,5'R)-3',5'-bis<(tert-butyldimethylsilyl)oxy>-4'-hydroxycyclohexylidene>acetic acid methyl ester 

Relevant articles and documents

Synthesis of a-ring synthon of 19-nor-1alpha,25-dihydroxyvitamin D3 from (D)-glucose

The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (D)-glucose.

Novel synthesis of 2-substituted 19-norvitamin D A-ring phosphine oxide from D-glucose as a building block

19-Norvitamin D A-ring phosphine oxide 5 was synthesized by a new sequence mode starting from D-glucose as a chiral template. Transformation of the pyranoside ring into the A-ring carbocycle was achieved by the Pd-catalyzed Ferrier rearrangement. The phosphine oxide 5 was obtained in an 18% overall yield by this novel cost-effective method.

19-Nor-vitamin D3 compounds with substitutent at 2-position

The 2α and 2β-hydroxy as well as the 2α(3'-hydroxypropoxy)- and 2β(3'-hydroxypropoxy)- and 2α(benzyloxy)- analogs of 19-nor-1α,25-dihydroxyvitamin D3 are disclosed. The two 2-hydroxy analogs showed in vivo calcium transport with little or no bo

Synthesis and biological activity of 2-hydroxy and 2-alkoxy analogs of 1α,25-dihydroxy-19-norvitamin D3

1α,2α,25-Trihydroxy-19-norvitamin D3, 1α,2β,25-trihydroxy-19- norvitamin D3, and their alkoxy analogs were efficiently prepared in a convergent synthesis, starting with (-)-quinic acid and a Windaus-Grundmann type ketone. Configurati