1414258-40-4Relevant academic research and scientific papers
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
McAllister, Laura A.,Montgomery, Justin I.,Abramite, Joseph A.,Reilly, Usa,Brown, Matthew F.,Chen, Jinshan M.,Barham, Rose A.,Che, Ye,Chung, Seung Won,Menard, Carol A.,Mitton-Fry, Mark,Mullins, Lisa M.,Noe, Mark C.,O'Donnell, John P.,Oliver III, Robert M.,Penzien, Joseph B.,Plummer, Mark,Price, Loren M.,Shanmugasundaram, Veerabahu,Tomaras, Andrew P.,Uccello, Daniel P.
, p. 6832 - 6838,7 (2020/09/02)
The synthesis and antibacterial activity of heterocyclic methylsulfone hydroxamates is presented. Compounds in this series are potent inhibitors of the LpxC enzyme, a key enzyme involved in the production of lipopolysaccharide (LPS) found in the outer membrane of Gram-negative bacteria. SAR evaluation of compounds in this series revealed analogs with potent antibacterial activity against challenging Gram-negative species such as Pseudomonas aeruginosa and Klebsiella pneumoniae.
