18355-77-6

Basic information

• Product Name: 2,3-DIFLUORO BENZALDEHYDE OXIME
• Synonyms: 2,3-DIFLUORO BENZALDEHYDE OXIME;2,3-DIFLURO BENZALDEHYDE OXIME
• CAS NO: 18355-77-6
• Molecular Formula: C₇H₅F₂NO
• Molecular Weight: 157.12
• Mol File: 18355-77-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-DIFLUORO BENZALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO BENZALDEHYDE OXIME(18355-77-6)
• EPA Substance Registry System: 2,3-DIFLUORO BENZALDEHYDE OXIME(18355-77-6)

Safety Data

• Hazardous Substances Data: 18355-77-6(Hazardous Substances Data)

Upstream product

• 2646-91-5 2,3-difluorobenzaldehyde 

Downstream Products

• 247091-92-5 2,3-difluorobenzoylchloride oxime 
• 1414258-40-4 C₁₅H₁₆F₂N₂O₅S 

Relevant articles and documents

Triazole alcohol derivative as well as preparation method and application thereof

The invention relates to a triazole alcohol derivative as well as a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is shown as a formula I, R1 represents a benzene ring or a substituted benzene ring, and substituent groups of the substituted benzene ring can be located at all positions of the benzene ring, can be mono-substituted or multi-substituted, and can be selected from a) halogen which is F and Cl; b) an electron withdrawing group which is cyano or trifluoromethyl; c ) a lower alkyl of 1-4 carbon atoms or a halogen substituted loweralkyl; and d) lower alkoxy of 1-4 carbon atoms or halogen substituted lower alkoxy. The compound of the invention has strong antifungal activity, has the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.

Design, synthesis, and in vitro evaluation of novel antifungal triazoles

Twenty-nine novel triazole analogues of ravuconazole and isavuconazole were designed and synthesized. Most of the compounds exhibited potent in vitro antifungal activities against 8 fungal isolates. Especially, compounds a10, a13, and a14 exhibited superior or comparable antifungal activity to ravuconazole against all the tested fungi. Structure-activity relationship study indicated that replacing 4-cyanophenylthioazole moiety of ravuconazole with fluorophenylisoxazole resulted in novel antifungal triazoles with more effectiveness and a broader-spectrum.

AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF A7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of ot7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.