1414573-15-1Relevant articles and documents
Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation
Agafonova, Natalia A.,Borisevich, Sophia S.,Burgart, Yanina V.,Chupakhin, Oleg N.,Evstigneeva, Natalia P.,Gerasimova, Natalia A.,Krasnykh, Olga P.,Kungurov, Nikolai V.,Kushch, Svetlana O.,Makhaeva, Galina F.,Maslova, Vera V.,Rudakova, Elena V.,Saloutin, Victor I.,Shchegolkov, Evgeny V.,Solodnikov, Sergey Yu.,Triandafilova, Galina A.,Ulitko, Maria V.,Zilberberg, Natalia V.
supporting information, (2020/09/16)
4-Nitroso-3-trifluoromethyl-5-alkyl[(het)aryl]pyrazoles were synthesized via one-pot nitrosation of 1,3-diketones or their lithium salts followed by treatment of hydrazines. Reduction of nitroso-derivatives made it possible to obtain 4-amino-3-trifluorome
N-BICYCLIC ARYL,N'-PYRAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
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Paragraph 00620, (2014/06/11)
Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.