1414930-06-5

Upstream product

• 1414930-05-4 2-(2-methylthioethyl)-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]adenine 
• 701-99-5 Phenoxyacetyl chloride 
• 133519-49-0 6-amino-9-{(2R,4S,5R)-4-(tert-butyldimethylsilyloxy)-5-[(tert-butyldimethylsilyloxy)methyl]tetrahydrofuran-2-yl}-2-iodo-9H-purine 
• 133519-55-8 2-vinyl-9-<2-deoxy-3,5-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>adenine 

Downstream Products

• 1414930-07-6 2-(2-methylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-β-D-ribofuranosyl) purine 
• 1414930-09-8 2-(2-methylthioethyl)-6-phenoxyacetylamino-1-[2-(2’deoxy-3’-N,N-diisopropyl cyanoethylphosphoramidyl)-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl]purine 

Relevant academic research and scientific papers

Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity

Oligodeoxynucleotides (ODNs) have been widely used for inhibiting the gene expression in antisense or antigene methods, and the interstrand cross-linking (ICL) forming ODNs have been expected to ensure the inhibition by these methods. Previously, we reported a highly efficient and selective ICL reaction toward cytosine using the 2-amino-6-vinylpurine derivative under acidic conditions. In this Letter, we report the synthesis of ODN containing 6-amino-2-vinylpurine derivatives and evaluation of the cross-linking reactivity.