1414964-98-9Relevant academic research and scientific papers
High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones
Cholewiak, Agnieszka,Adamczyk, Kamil,Kopyt, Micha?,Kasztelan, Adrian,Kwiatkowski, Piotr
, p. 4365 - 4371 (2018/06/22)
The application of high pressure (up to 9 kbar) allows for relatively fast (1-5 h) and highly enantioselective 1,4-addition of nitromethane and 2-nitropropane to chalcones at room temperature with substantial reduction of catalyst loading (0.2-1 mol% of cinchona alkaloid-based thioureas and squaramides). Various γ-nitroketones were obtained at 9 kbar with high yield and enantioselectivity (up to 98%), whereas in control experiments at atmospheric pressure usually only a small amount (10%) of products were formed after 20 h.
Enantioselective decarboxylative Michael addition of β-ketoacids to nitroalkenes catalyzed by binaphthyl-derived organocatalysts
Moon, Hyoung Wook,Kim, Dae Young
, p. 6569 - 6572,4 (2012/12/11)
The catalytic enantioselective decarboxylative Michael addition reaction promoted by chiral bifunctional organocatalysts has been developed, allowing facile synthesis of the corresponding γ-nitro ketones with excellent enantioselectivity (up to 97% ee). The method reported represents a valuable approach utilizing β-ketoacids as synthetic equivalents of aryl methyl ketones.
Enantioselective decarboxylative Michael addition of β-ketoacids to nitroalkenes catalyzed by binaphthyl-derived organocatalysts
Moon, Hyoung Wook,Kim, Dae Young
, p. 6569 - 6572 (2013/01/15)
The catalytic enantioselective decarboxylative Michael addition reaction promoted by chiral bifunctional organocatalysts has been developed, allowing facile synthesis of the corresponding γ-nitro ketones with excellent enantioselectivity (up to 97% ee). The method reported represents a valuable approach utilizing β-ketoacids as synthetic equivalents of aryl methyl ketones.
