1414975-23-7Relevant academic research and scientific papers
Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein-ligand crystallography
Matijssen, Cornelis,Silva-Santisteban, M. Cris,Westwood, Isaac M.,Siddique, Samerene,Choi, Vanessa,Sheldrake, Peter,Van Montfort, Rob L.M.,Blagg, Julian
supporting information, p. 6630 - 6639 (2013/01/15)
Two closely related binding modes have previously been proposed for the ATP-competitive benzimidazole class of checkpoint kinase 2 (CHK2) inhibitors; however, neither binding mode is entirely consistent with the reported SAR. Unconstrained rigid docking o
2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2
Neff, Danielle K.,Lee-Dutra, Alice,Blevitt, Jonathan M.,Axe, Frank U.,Hack, Michael D.,Buma, Johnathan C.,Rynberg, Raymond,Brunmark, Anders,Karlsson, Lars,Breitenbucher, J. Guy
, p. 6467 - 6471 (2008/09/17)
A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to inve
