1415020-24-4

Basic information

• Product Name: C₁₅H₁₃FO₃
• Synonyms: C₁₅H₁₃FO₃
• CAS NO: 1415020-24-4
• Molecular Weight: 260.265
• Mol File: 1415020-24-4.mol

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₃FO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₃FO₃(1415020-24-4)
• EPA Substance Registry System: C₁₅H₁₃FO₃(1415020-24-4)

Safety Data

• Hazardous Substances Data: 1415020-24-4(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 97071-44-8 C₁₆H₁₃FN₂OS 

Relevant articles and documents

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors

A series of 4,5-diaryl-1H-imidazole-2(3H)-thione was synthesized and their inhibitory potency against soybean 15-lipoxygenase and free radical scavenging activities were determined. Compound 11 showed the best IC50 for 15-LOX inhibition (IC50 = 4.7 μM) and free radical scavenging activity (IC50 = 14 μM). Methylation of SH at C2 position of imidazole has dramatically decreased the 15-LOX inhibition and radical scavenging activity as it can be observed in the inactive compound 14 (IC50 >250 μM). Structure activity similarity (SAS) showed that the most important chemical modification in this series was methylation of SH group and Docking studies revealed a proper orientation for SH group towards Fe core of the 15-LOX active site. Therefore it was concluded that iron chelating could be a possible mechanism for enzyme inhibition in this series of compounds.