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1415026-30-0

[1-phenyl-3-(thiophen-3-yl)-1H-pyrazol-4-yl][4-(4-trifluoromethylphenyl)piperazin-1-yl]methanone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1415026-30-0 Structure

  • Basic information

    1. Product Name: [1-phenyl-3-(thiophen-3-yl)-1H-pyrazol-4-yl][4-(4-trifluoromethylphenyl)piperazin-1-yl]methanone
    2. Synonyms:
    3. CAS NO:1415026-30-0
    4. Molecular Formula:
    5. Molecular Weight: 482.529
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1415026-30-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [1-phenyl-3-(thiophen-3-yl)-1H-pyrazol-4-yl][4-(4-trifluoromethylphenyl)piperazin-1-yl]methanone(CAS DataBase Reference)
    10. NIST Chemistry Reference: [1-phenyl-3-(thiophen-3-yl)-1H-pyrazol-4-yl][4-(4-trifluoromethylphenyl)piperazin-1-yl]methanone(1415026-30-0)
    11. EPA Substance Registry System: [1-phenyl-3-(thiophen-3-yl)-1H-pyrazol-4-yl][4-(4-trifluoromethylphenyl)piperazin-1-yl]methanone(1415026-30-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1415026-30-0(Hazardous Substances Data)

1415026-30-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1415026-30-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,5,0,2 and 6 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1415026-30:
(9*1)+(8*4)+(7*1)+(6*5)+(5*0)+(4*2)+(3*6)+(2*3)+(1*0)=110
110 % 10 = 0
So 1415026-30-0 is a valid CAS Registry Number.

1415026-30-0Downstream Products

1415026-30-0Relevant articles and documents

Synthesis of ester and amide derivatives of 1-phenyl-3-(thiophen-3-yl)-1H- pyrazole-4-carboxylic acid and study of their anticancer activity

Inceler, Nazan,Yilmaz, Akin,Baytas, Sultan Nacak

, p. 3109 - 3118 (2013)

A series of novel thiophene containing 1,3-diarylpyrazole derivatives were synthesized and the structures were determined by IR, 1H-NMR, and HRMS analysis. The anticancer activity of the title compounds against MCF7, MDA-MB-231, HeLa, Raji, and HL60 human cancer cells growth were investigated by MTT assay. Interestingly, Raji and HL60 cells exhibited more sensitivity to synthesized compounds. (4-Benzyl-piperidin-1-yl)-(1-phenyl-3-thiophen-3-yl-1H- pyrazol-4-yl)-methanone (4c) possessed the highest growth inhibitory effect on Raji and HL60 cancer cells (GI50 25.2 ± 3.2 and 28.3 ± 1.53 μM, respectively). Compound 4f, 4-trifluoromethylphenyl piperazine at the amide part, also showed potent activity on Raji and HL60 cancer cell lines with a GI50 value of 32.0 ± 1.27 and 36.7 ± 2.15 μM, respectively. Physicochemical properties of the synthesized compounds were evaluated in silico, and it was found that all compounds should present good passive oral absorption. All synthesized compounds demonstrated good drug-likeness values. The data suggested that these compounds might be promising for further development.

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