14151-88-3

Usage

Uses

Used in Pharmaceutical Industry:
BENZO[F][1,4]OXAZEPINE-3,5-DIONE is used as a key intermediate in the synthesis of various pharmaceutical drugs for its unique structural properties and reactivity. It plays a crucial role in the development of new medications targeting a range of medical conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, BENZO[F][1,4]OXAZEPINE-3,5-DIONE is employed as a valuable molecule for drug discovery. Its potential in the treatment of various medical conditions makes it an important compound for designing and developing innovative therapeutic agents.
Used in Organic Chemistry:
BENZO[F][1,4]OXAZEPINE-3,5-DIONE is also utilized in organic chemistry due to its distinctive structural properties and reactivity. It serves as a building block for the creation of complex organic molecules and contributes to the advancement of chemical synthesis techniques.

Upstream product

• 90074-90-1 2-(ethoxycarbonylmethyloxy)benzamide 
• 25395-22-6 2-(2-carbamoylphenoxy)acetic acid 
• 65-45-2 salicylamide 

Downstream Products

• 182415-09-4 Piclozotan 
• 131112-58-8 4-[4-[4-(2-pyrimidinyl)piperazin-1-yl]butyl]-1,4-benzoxazepine-3,5(2H,4H)-dione 

Relevant academic research and scientific papers

Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan

A new series of 1,4-benzoxazepine derivatives was designed, synthesized, and evaluated for binding to 5-HT1A receptor and cerebral anti-ischemic effect. A lot of compounds exhibited nanomolar affinity for 5-HT1A receptor with good selectivity over both dopamine D 2 and α1-adrenergic receptors. Among these compounds, 3-chloro-4-[4-[4-(2-pyridinyl)-1,2,3,6-tetrahydropyridin-1-yl]butyl]- 1, 4-benzoxazepin-5(4H)-one (50: SUN N4057 (Piclozotan) as 2HCl salt) showed remarkable neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model.

New 5-HT1A receptor agonists possessing 1,4-benzoxazepine scaffold exhibit highly potent anti-ischemic effects.

A series of new 3-substituted-4-(4-aminobutyl)-1,4-benzoxazepin-5(4H)-one derivatives (1-5) which showed a very high affinity for 5-HT1A receptor with good selectivity over dopamine D2 receptor was synthesized. Among these compounds, 3-chloro-4-[4-[4-(2-p