182415-09-4Relevant articles and documents
New 5-HT1A receptor agonists possessing 1,4-benzoxazepine scaffold exhibit highly potent anti-ischemic effects.
Kamei,Maeda,Ogino,Koyama,Nakajima,Tatsuoka,Ohno,Inoue
, p. 595 - 598 (2001)
A series of new 3-substituted-4-(4-aminobutyl)-1,4-benzoxazepin-5(4H)-one derivatives (1-5) which showed a very high affinity for 5-HT1A receptor with good selectivity over dopamine D2 receptor was synthesized. Among these compounds, 3-chloro-4-[4-[4-(2-p
Pyrimidine derivatives and their salts, useful for making benzoxazepine derivatives
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Example 86, (2010/11/29)
A benzoxazepine derivative having the general formula (I) and its salts and medicaments containing the same as effective ingredients: wherein, n is an integer of 2 to 5, R1indicates a hydrogen atom, halogen atom, C1to C4lo
Process of production of 4-substituted-3-halogeno-1,4-benzoxazepine derivative and salts thereof
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, (2008/06/13)
A process for producing 4-substituted-3-halogeno-1,4-benzoxazepin derivative or the salt thereof comprising: deprotonizing a benzoxazepine derivative having the formula (II): STR1 with a base; and then, reacting the deprotonized product with a phosphate halide to produce an intermediate having the formula (IV): STR2 and then, reacting the resultant intermediate (IV) with a reagent selected from (i) a complex of a phosphine with chlorine or bromine, (ii) a phosphine and a chlorine gas or liquid bromine, (iii) a phosphine and tetrachloromethane or tetrabromomethane, or (iv) a halogenated phosphite ester to produce a 4-substituted-3-halogeno-1,4-benzoxazepine derivative having the formula (I) STR3 wherein X indicates a chlorine atom or a bromine atom, or its salt.
