1415219-29-2

Upstream product

• 1415219-60-1 1-(4,5-Dihydro-5-(3-methoxy-4-(prop-2-ynyloxy)phenyl)-3-phenylpyrazol-1-yl)ethanone 
• 17271-88-4 p-nitrobenzyl azide 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 1290604-83-9 1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole 
• 89406-16-6 (2E)-3-(4-hydroxyphenyl-3-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 98-86-2 acetophenone 
• 121-33-5 vanillin 

Relevant academic research and scientific papers

Synthesis of 1,2,3-triazole tethered bifunctional hybrids by click chemistry and their cytotoxic studies

In view of the drug resistance with most of the currently used anticancer drugs, molecular hybrids of pyrazolyl chalcones and p-nitro benzyl functionalities tethered by triazole ring have been synthesised and evaluated for cytotoxic studies against three human cancer cell lines (THP, COLO-205, A-549). The results of the preliminary investigation exhibited marked dependence of the cytotoxic activity on the electronic factors. Placement of naphthyl (JGPT-11) and trimethoxy phenyl ring (JGPT-6) as ring A proved to be extremely beneficial in enhancing the cytotoxic potential. Thus we herein report the synthesis and cytotoxic studies of a new class of molecular hybrids. Detailed investigation on the biological mechanistic insights of JGPT-11 and 6 is under progress.