1415246-91-1Relevant articles and documents
Highly regioselective nitrile oxide dipolar cycloadditions with ortho-nitrophenyl alkynes
McIntosh, Melissa L.,Naffziger, Michael R.,Ashburn, Bradley O.,Carter, Rich G.,Zakharov, Lev N.
, p. 9204 - 9213,10 (2012/12/12)
The dipolar cycloadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent functionalization of the isoxazole scaffold has been demonstrated.