1415306-80-7Relevant academic research and scientific papers
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions
Schaefer, Gesa,Milic, Jelena,Eldahshan, Adeeb,Goetz, Frank,Zuehlke, Kerstin,Schillinger, Christian,Kreuchwig, Annika,Elkins, Jonathan M.,Abdulazeez, Kamal R.,Oder, Andreas,Moutty, Marie C.,Masada, Nanako,Beerbaum, Monika,Schlegel, Brigitte,Niquet, Sylvia,Schmieder, Peter,Krause, Gerd,Vonkries, Jens Peter,Cooper, Dermot M. F.,Knapp, Stefan,Rademann, Joerg,Rosenthal, Walter,Klussmann, Enno
, p. 12187 - 12191 (2013)
A good fit: Interactions between A-kinase anchoring proteins (AKAPs) and protein kinaseA (PKA) play key roles in a plethora of physiologically relevant processes whose dysregulation causes or is associated with diseases such as heart failure. Terpyridines have been developed as α-helix mimetics for the inhibition of such interactions and are the first biologically active, nonpeptidic compounds that block the AKAP binding site of PKA.
