1415326-38-3

Basic information

• Product Name: C₂₅H₂₉N₃O₁₂
• Synonyms: C₂₅H₂₉N₃O₁₂
• CAS NO: 1415326-38-3
• Molecular Weight: 563.518
• Mol File: 1415326-38-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₉N₃O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₉N₃O₁₂(1415326-38-3)
• EPA Substance Registry System: C₂₅H₂₉N₃O₁₂(1415326-38-3)

Safety Data

• Hazardous Substances Data: 1415326-38-3(Hazardous Substances Data)

Upstream product

• 83476-52-2 propargyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 16714-23-1 2-azido-benzoic acid methyl ester 
• 134-20-3 2-carbomethoxyaniline 
• 118-48-9 isatoic anhydride 

Downstream Products

• 1415326-54-3 C₁₇H₂₁N₃O₈ 

Relevant articles and documents

Synthesis and cytotoxicity of some d-mannose click conjugates with aminobenzoic acid derivatives

Two sets of new conjugates obtained from d-mannose derivatives and o-, m-, and p-substituted benzoic acid esters interconnected through a triazole ring were synthesized by Cu(I) catalyzed azide-alkyne cycloaddition. All synthesized compounds were tested for their in vitro cytotoxic activity against seven cancer cell lines with/without multidrug resistance phenotype as well as non-tumor MRC-5 and BJ fibroblasts. Butyl ester of 4-aminobenzoic acid 6c showed the highest activity among all tested compounds, however, it was active only against K562 myeloid leukemia cells. N-Glycosyltriazole conjugates, both acetylated and nonacetylated at mannose moiety, were almost completely inactive. In contrast, some of the acetylated O-glycosyl conjugates showed cytotoxic activity which was cell line dependent and strongly affected by position of benzoic acid substitution as well as a length of its ester alkyl chain; the most potent compound was acetylated mannoside conjugated with octyl ester of m-substituted benzoic acid. However, deacetylation resulting in hydrophilicity increase of the glycosides almost completely abolished their cytotoxic potency.