1415338-20-3Relevant academic research and scientific papers
Asymmetric addition of benzothiazole to N-tert-butanesulfinyl imine for the synthesis of chiral α-branched heteroaryl amines
Zhang, Jinlong,Yang, Yuhong,Wang, Mei,Lin, Li,Wang, Rui
supporting information, p. 6893 - 6896 (2013/01/15)
This work concerns the asymmetric additions of benzothiazole to a variety of N-tert-butanesulfinyl imines with excellent diastereoselectivities (d.r. up to >99:1). Amino alkoxyl lithium was the key additive to obtain the excellent diastereoselectivity. More functionalized 4-methyl-5-vinyl thiazole and alkyl imines which can isomerize to enamines are also compatible substrates to the present protocol.
